5DI ; DIOI ; Type 1 DI ; Type-I 5'-deiodinase ; ITDI1 ; TXDI1
Categories
Elisa
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Specificity
Natural and recombinant Human Type I iodothyronine deiodinase
Subcellular Location
Endoplasmic reticulum membrane Single-pass membrane protein