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ELISA Kit for Human Two pore calcium channel protein 2

SKU : BHE13810710

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E4486h
Alternative Names	Voltage-dependent calcium channel protein TPC2 ; TPC2
Categories	Elisa
Function	Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
Specificity	Natural and recombinant Human Two pore calcium channel protein 2
Subcellular Location	Lysosome membrane Multi-pass membrane protein Only the acidic lysosomal fraction is sensitive to NAADP.
Detection Range	1.56-100ng/mL
Entryname	TPC2_HUMAN
Method Type	Competitive
Platform	PF00520
Protein Name	Two pore calcium channel protein 2
Sensitivity	0.78ng/mL
Sequence	50: MAEPQAESEP ; LLGGARGGGG ; DWPAGLTTYR ; SIQVGPGAAA ; RWDLCIDQAV ; 100: VFIEDAIQYR ; SINHRVDASS ; MWLYRRYYSN ; VCQRTLSFTI ; FLILFLAFIE ; 150: TPSSLTSTAD ; VRYRAAPWEP ; PCGLTESVEV ; LCLLVFAADL ; SVKGYLFGWA ; 200: HFQKNLWLLG ; YLVVLVVSLV ; DWTVSLSLVC ; HEPLRIRRLL ; RPFFLLQNSS ; 250: MMKKTLKCIR ; WSLPEMASVG ; LLLAIHLCLF ; TMFGMLLFAG ; GKQDDGQDRE ; 300: RLTYFQNLPE ; SLTSLLVLLT ; TANNPDVMIP ; AYSKNRAYAI ; FFIVFTVIGS ; 350: LFLMNLLTAI ; IYSQFRGYLM ; KSLQTSLFRR ; RLGTRAAFEV ; LSSMVGEGGA ; 400: FPQAVGVKPQ ; NLLQVLQKVQ ; LDSSHKQAMM ; EKVRSYGSVL ; LSAEEFQKLF ; 450: NELDRSVVKE ; HPPRPEYQSP ; FLQSAQFLFG ; HYYFDYLGNL ; IALANLVSIC ; 500: VFLVLDADVL ; PAERDDFILG ; ILNCVFIVYY ; LLEMLLKVFA ; LGLRGYLSYP ; 550: SNVFDGLLTV ; VLLVLEISTL ; AVYRLPHPGW ; RPEMVGLLSL ; WDMTRMLNML ; 600: IVFRFLRIIP ; SMKLMAVVAS ; TVLGLVQNMR ; AFGGILVVVY ; YVFAIIGINL ; 650: FRGVIVALPG ; NSSLAPANGS ; APCGSFEQLE ; YWANNFDDFA ; AALVTLWNLM ; 700: VVNNWQVFLD ; AYRRYSGPWS ; KIYFVLWWLV ; SSVIWVNLFL ; ALILENFLHK ; 750: WDPRSHLQPL ; AGTPEATYQM ; TVELLFRDIL ; EEPGEDELTE ; RLSQHPHLWL ; 752: CR
Sequence Length	752
String	Q8NHX9
Sub Unit	Homodimer.

Uniprot	Q8NHX9
Gene Name	TPCN2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:219931
Unigene	Hs.131851

Reference	1. "NAADP mobilizes calcium from acidic organelles through two-pore channels." Calcraft P.J., Ruas M., Pan Z., Cheng X., Arredouani A., Hao X., Tang J., Rietdorf K., Teboul L., Chuang K.T., Lin P., Xiao R., Wang C., Zhu Y., Lin Y., Wyatt C.N., Parrington J., Ma J., Evans A.M., Galione A., Zhu M.X.more... Nature459:596-600(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS PRO-564 AND GLU-734 2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.more... Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS PRO-564 AND GLU-734 tissue: Blood. 4. "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.more... BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 382-752;VARIANTS PRO-564 AND GLU-734 tissue: Testis. 5. "Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling." Brailoiu E., Churamani D., Cai X., Schrlau M.G., Brailoiu G.C., Gao X., Hooper R., Boulware M.J., Dun N.J., Marchant J.S., Patel S. J. Cell Biol.186:201-209(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION 6. "Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP." Gomez-Suaga P., Luzon-Toro B., Churamani D., Zhang L., Bloor-Young D., Patel S., Woodman P.G., Churchill G.C., Hilfiker S. Hum. Mol. Genet.21:511-525(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRRK2 7. "Two newly identified genetic determinants of pigmentation in Europeans." Sulem P., Gudbjartsson D.F., Stacey S.N., Helgason A., Rafnar T., Jakobsdottir M., Steinberg S., Gudjonsson S.A., Palsson A., Thorleifsson G., Palsson S., Sigurgeirsson B., Thorisdottir K., Ragnarsson R., Benediktsdottir K.R., Aben K.K., Vermeulen S.H., Goldstein A.M., Tucker M.A., Kiemeney L.A., Olafsson J.H., Gulcher J., Kong A., Thorsteinsdottir U., Stefansson K.more... Nat. Genet.40:835-837(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-484 AND GLU-734;ASSOCIATION WITH SHEP10

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