Apo-3 ; Apoptosis-inducing receptor AIR ; Apoptosis-mediating receptor DR3 ; Apoptosis-mediating receptor TRAMP ; Death receptor 3 ; Lymphocyte-associated receptor of death ; LARD ; Protein WSL ; Protein WSL-1 ; APO3 ; DDR3 ; DR3 ; TNFRSF12 ; WSL ; WSL1 ; UNQ455/PRO779
Categories
Elisa
Function
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Specificity
Natural and recombinant Human Tumor necrosis factor receptor superfamily member 25
Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.