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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1A

SKU : BHE13810825

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0131h
Alternative Names	Tumor necrosis factor receptor 1 ; TNF-R1 ; Tumor necrosis factor receptor type I ; TNF-RI ; p55 ; p60 ; CD120a ; TNFAR ; TNFR1
Categories	Elisa
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Specificity	Natural and recombinant Human Tumor necrosis factor receptor superfamily member 1A
Subcellular Location	Cell membrane Single-pass type I membrane protein Secreted
Detection Range	15.6-1000pg/mL
Entryname	TNR1A_HUMAN
Method Type	Sandwich
Platform	PF00531
Protein Name	Tumor necrosis factor receptor superfamily member 1A
Sensitivity	10pg/mL
Sequence	50: MGLSTVPDLL ; LPLVLLELLV ; GIYPSGVIGL ; VPHLGDREKR ; DSVCPQGKYI ; 100: HPQNNSICCT ; KCHKGTYLYN ; DCPGPGQDTD ; CRECESGSFT ; ASENHLRHCL ; 150: SCSKCRKEMG ; QVEISSCTVD ; RDTVCGCRKN ; QYRHYWSENL ; FQCFNCSLCL ; 200: NGTVHLSCQE ; KQNTVCTCHA ; GFFLRENECV ; SCSNCKKSLE ; CTKLCLPQIE ; 250: NVKGTEDSGT ; TVLLPLVIFF ; GLCLLSLLFI ; GLMYRYQRWK ; SKLYSIVCGK ; 300: STPEKEGELE ; GTTTKPLAPN ; PSFSPTPGFT ; PTLGFSPVPS ; STFTSSSTYT ; 350: PGDCPNFAAP ; RREVAPPYQG ; ADPILATALA ; SDPIPNPLQK ; WEDSAHKPQS ; 400: LDTDDPATLY ; AVVENVPPLR ; WKEFVRRLGL ; SDHEIDRLEL ; QNGRCLREAQ ; 450: YSMLATWRRR ; TPRREATLEL ; LGRVLRDMDL ; LGCLEDIEEA ; LCGPAALPPA ; 455: PSLLR
Sequence Length	455
String	P19438
Sub Unit	Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein.

Uniprot	P19438
Gene Name	TNFRSF1A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7132
Unigene	Hs.279594

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810825	E0131h	96T	$536		Add to Cart

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