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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Tumor necrosis factor alpha-induced protein 3

SKU : BHE13810464

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9843h
Alternative Names	OTU domain-containing protein 7C ; Putative DNA-binding protein A20 ; Zinc finger protein A20 ; OTUD7C
Categories	Elisa
Function	Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. In vitro able to deubiquitinate both 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system.
Specificity	Natural and recombinant Human Tumor necrosis factor alpha-induced protein 3
Subcellular Location	Cytoplasm Nucleus
Detection Range	0.312-20ng/mL
Entryname	TNAP3_HUMAN
Method Type	Sandwich
Platform	PF02338
Protein Name	Tumor necrosis factor alpha-induced protein 3
Sensitivity	0.1ng/mL
Sequence	50: MAEQVLPQAL ; YLSNMRKAVK ; IRERTPEDIF ; KPTNGIIHHF ; KTMHRYTLEM ; 100: FRTCQFCPQF ; REIIHKALID ; RNIQATLESQ ; KKLNWCREVR ; KLVALKTNGD ; 150: GNCLMHATSQ ; YMWGVQDTDL ; VLRKALFSTL ; KETDTRNFKF ; RWQLESLKSQ ; 200: EFVETGLCYD ; TRNWNDEWDN ; LIKMASTDTP ; MARSGLQYNS ; LEEIHIFVLC ; 250: NILRRPIIVI ; SDKMLRSLES ; GSNFAPLKVG ; GIYLPLHWPA ; QECYRYPIVL ; 300: GYDSHHFVPL ; VTLKDSGPEI ; RAVPLVNRDR ; GRFEDLKVHF ; LTDPENEMKE ; 350: KLLKEYLMVI ; EIPVQGWDHG ; TTHLINAAKL ; DEANLPKEIN ; LVDDYFELVQ ; 400: HEYKKWQENS ; EQGRREGHAQ ; NPMEPSVPQL ; SLMDVKCETP ; NCPFFMSVNT ; 450: QPLCHECSER ; RQKNQNKLPK ; LNSKPGPEGL ; PGMALGASRG ; EAYEPLAWNP ; 500: EESTGGPHSA ; PPTAPSPFLF ; SETTAMKCRS ; PGCPFTLNVQ ; HNGFCERCHN ; 550: ARQLHASHAP ; DHTRHLDPGK ; CQACLQDVTR ; TFNGICSTCF ; KRTTAEASSS ; 600: LSTSLPPSCH ; QRSKSDPSRL ; VRSPSPHSCH ; RAGNDAPAGC ; LSQAARTPGD ; 650: RTGTSKCRKA ; GCVYFGTPEN ; KGFCTLCFIE ; YRENKHFAAA ; SGKVSPTASR ; 700: FQNTIPCLGR ; ECGTLGSTMF ; EGYCQKCFIE ; AQNQRFHEAK ; RTEEQLRSSQ ; 750: RRDVPRTTQS ; TSRPKCARAS ; CKNILACRSE ; ELCMECQHPN ; QRMGPGAHRG ; 790: EPAPEDPPKQ ; RCRAPACDHF ; GNAKCNGYCN ; ECFQFKQMYG ;
Sequence Length	790
String	P21580
Sub Unit	Homodimer. Interacts with NAF1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF.

Uniprot	P21580
Gene Name	TNFAIP3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7128
Unigene	Hs.211600

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810464	E9843h	96T	$736		Add to Cart

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