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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transforming protein RhoA

SKU : BHE13809677

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9513h
Alternative Names	Rho cDNA clone 12 ; h12 ; ARH12 ; ARHA ; RHO12
Categories	Elisa
Function	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Specificity	Natural and recombinant Human Transforming protein RhoA
Subcellular Location	Cell membrane Lipid-anchor Cytoplasmic side Cytoplasm cytoskeleton
Detection Range	0.156-10ng/mL
Entryname	RHOA_HUMAN
Method Type	Sandwich
Platform	PF00071
Protein Name	Transforming protein RhoA
Sensitivity	0.11ng/mL
Sequence	50: MAAIRKKLVI ; VGDGACGKTC ; LLIVFSKDQF ; PEVYVPTVFE ; NYVADIEVDG ; 100: KQVELALWDT ; AGQEDYDRLR ; PLSYPDTDVI ; LMCFSIDSPD ; SLENIPEKWT ; 150: PEVKHFCPNV ; PIILVGNKKD ; LRNDEHTRRE ; LAKMKQEPVK ; PEEGRDMANR ; 193: IGAFGYMECS ; AKTKDGVREV ; FEMATRAALQ ; ARRGKKKSGC ; LVL
Sequence Length	193
String	P61586
Sub Unit	Interacts with RGNEF (By similarity). Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2, ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts (in the constitutively activated, GTP-bound form) with DGKQ. Interacts with human respiratory syncytial virus (HRSV) protein F; this interaction facilitates virus-induced syncytium formation. Interacts with GNB2L1/RACK1; enhances RHOA activation.

Uniprot	P61586
Gene Name	RHOA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:387
Unigene	Hs.247077

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809677	E9513h	96T	$736		Add to Cart

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