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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transcription factor Sp1

SKU : BHE13810568

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15093h
Alternative Names	TSFP1
Categories	Elisa
Function	Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Specificity	Natural and recombinant Human Transcription factor Sp1
Subcellular Location	Nucleus Cytoplasm Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.
Detection Range	78-5000pg/mL
Entryname	SP1_HUMAN
Method Type	Sandwich
Platform	PF00096
Protein Name	Transcription factor Sp1
Sensitivity	39pg/mL
Sequence	50: MSDQDHSMDE ; MTAVVKIEKG ; VGGNNGGNGN ; GGGAFSQARS ; SSTGSSSSTG ; 100: GGGQESQPSP ; LALLAATCSR ; IESPNENSNN ; SQGPSQSGGT ; GELDLTATQL ; 150: SQGANGWQII ; SSSSGATPTS ; KEQSGSSTNG ; SNGSESSKNR ; TVSGGQYVVA ; 200: AAPNLQNQQV ; LTGLPGVMPN ; IQYQVIPQFQ ; TVDGQQLQFA ; ATGAQVQQDG ; 250: SGQIQIIPGA ; NQQIITNRGS ; GGNIIAAMPN ; LLQQAVPLQG ; LANNVLSGQT ; 300: QYVTNVPVAL ; NGNITLLPVN ; SVSAATLTPS ; SQAVTISSSG ; SQESGSQPVT ; 350: SGTTISSASL ; VSSQASSSSF ; FTNANSYSTT ; TTTSNMGIMN ; FTTSGSSGTN ; 400: SQGQTPQRVS ; GLQGSDALNI ; QQNQTSGGSL ; QAGQQKEGEQ ; NQQTQQQQIL ; 450: IQPQLVQGGQ ; ALQALQAAPL ; SGQTFTTQAI ; SQETLQNLQL ; QAVPNSGPII ; 500: IRTPTVGPNG ; QVSWQTLQLQ ; NLQVQNPQAQ ; TITLAPMQGV ; SLGQTSSSNT ; 550: TLTPIASAAS ; IPAGTVTVNA ; AQLSSMPGLQ ; TINLSALGTS ; GIQVHPIQGL ; 600: PLAIANAPGD ; HGAQLGLHGA ; GGDGIHDDTA ; GGEEGENSPD ; AQPQAGRRTR ; 650: REACTCPYCK ; DSEGRGSGDP ; GKKKQHICHI ; QGCGKVYGKT ; SHLRAHLRWH ; 700: TGERPFMCTW ; SYCGKRFTRS ; DELQRHKRTH ; TGEKKFACPE ; CPKRFMRSDH ; 750: LSKHIKTHQN ; KKGGPGVALS ; VGTLPLDSGA ; GSEGSGTATP ; SALITTNMVA ; 785: MEAICPEGIA ; RLANSGINVM ; QVADLQSINI ; SGNGF
Sequence Length	785
String	P08047
Sub Unit	Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein. Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1 (By similarity). Interacts with ATF7IP and TBP.

Uniprot	P08047
Gene Name	SP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6667
Unigene	Hs.620754

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810568	E15093h	96T	$736		Add to Cart

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