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ELISA Kit for Human Transcription factor RelB

SKU : BHE13809750

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1732h
Alternative Names	I-Rel
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
Specificity	Natural and recombinant Human Transcription factor RelB
Subcellular Location	Nucleus Cytoplasm cytoskeleton centrosome Co-localizes with NEK6 in the centrosome.
Detection Range	0.156-10ng/ml
Entryname	RELB_HUMAN
Method Type	Sandwich
Platform	PF00554
Protein Name	Transcription factor RelB
Sensitivity	0.01ng/mL
Sequence	50: MLRSGPASGP ; SVPTGRAMPS ; RRVARPPAAP ; ELGALGSPDL ; SSLSLAVSRS ; 100: TDELEIIDEY ; IKENGFGLDG ; GQPGPGEGLP ; RLVSRGAASL ; STVTLGPVAP ; 150: PATPPPWGCP ; LGRLVSPAPG ; PGPQPHLVIT ; EQPKQRGMRF ; RYECEGRSAG ; 200: SILGESSTEA ; SKTLPAIELR ; DCGGLREVEV ; TACLVWKDWP ; HRVHPHSLVG ; 250: KDCTDGICRV ; RLRPHVSPRH ; SFNNLGIQCV ; RKKEIEAAIE ; RKIQLGIDPY ; 300: NAGSLKNHQE ; VDMNVVRICF ; QASYRDQQGQ ; MRRMDPVLSE ; PVYDKKSTNT ; 350: SELRICRINK ; ESGPCTGGEE ; LYLLCDKVQK ; EDISVVFSRA ; SWEGRADFSQ ; 400: ADVHRQIAIV ; FKTPPYEDLE ; IVEPVTVNVF ; LQRLTDGVCS ; EPLPFTYLPR ; 450: DHDSYGVDKK ; RKRGMPDVLG ; ELNSSDPHGI ; ESKRRKKKPA ; ILDHFLPNHG ; 500: SGPFLPPSAL ; LPDPDFFSGT ; VSLPGLEPPG ; GPDLLDDGFA ; YDPTAPTLFT ; 550: MLDLLPPAPP ; HASAVVCSGG ; AGAVVGETPG ; PEPLTLDSYQ ; APGPGDGGTA ; 579: SLVGSNMFPN ; HYREAAFGGG ; LLSPGPEAT
Sequence Length	579
String	Q01201
Sub Unit	Component of the NF-kappa-B RelB-p50 complex. Component of the NF-kappa-B RelB-p52 complex. Self-associates; the interaction seems to be transient and may prevent degradation allowing for heterodimer formation with p50 or p52. Interacts with NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.

Uniprot	Q01201
Gene Name	RELB
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5971
Unigene	Hs.654402

Reference	1. "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity." Ruben S.M., Klement J.F., Maher M., Coleman T.A., Chen C.H., Rosen C.A. Genes Dev.6:745-760(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: T-cell. 2. "A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping." Yoshiura K., Murray J.C. Submitted (1998-01) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 3. NHLBI resequencing and genotyping service (RS&G) Submitted (2005-12) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Blood. 5. "RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B." Ryseck R.P., Bull P., Takamiya M., Bours V., Siebenlist U., Dobrzanski P., Bravo R. Mol. Cell. Biol.12:674-684(1992) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE NF-KAPPA-B RELB-P50 COMPLEX 6. "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif." Dobrzanski P., Ryseck R.P., Bravo R. Mol. Cell. Biol.13:1572-1582(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION 7. "Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity." Dobrzanski P., Ryseck R.P., Bravo R. EMBO J.13:4608-4616(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE NF-KAPPA-B RELB-P50 COMPLEX;IDENTIFICATION IN THE NF-KAPPA-B RELB-P52 COMPLEX 8. "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-573;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Leukemic T-cell. 10. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome." Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J. J. Proteome Res.9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION 11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 12. "Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis." Hamidi T., Algul H., Cano C.E., Sandi M.J., Molejon M.I., Riemann M., Calvo E.L., Lomberk G., Dagorn J.C., Weih F., Urrutia R., Schmid R.M., Iovanna J.L. J. Clin. Invest.122:2092-2103(2012) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY NUPR1

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