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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transcription factor E2-alpha

SKU : BHE13810220

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14975h
Alternative Names	Class B basic helix-loop-helix protein 21 ; bHLHb21 ; Immunoglobulin enhancer-binding factor E12/E47 ; Immunoglobulin transcription factor 1 ; Kappa-E2-binding factor ; Transcription factor 3 ; TCF-3 ; Transcription factor ITF-1 ; BHLHB21 ; E2A ; ITF1
Categories	Elisa
Function	Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
Specificity	Natural and recombinant Human Transcription factor E2-alpha
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	TFE2_HUMAN
Method Type	Competitive
Platform	PF00010
Protein Name	Transcription factor E2-alpha
Sensitivity	0.19ng/ml
Sequence	50: MNQPQRMAPV ; GTDKELSDLL ; DFSMMFPLPV ; TNGKGRPASL ; AGAQFGGSGL ; 100: EDRPSSGSWG ; SGDQSSSSFD ; PSRTFSEGTH ; FTESHSSLSS ; STFLGPGLGG ; 150: KSGERGAYAS ; FGRDAGVGGL ; TQAGFLSGEL ; ALNSPGPLSP ; SGMKGTSQYY ; 200: PSYSGSSRRR ; AADGSLDTQP ; KKVRKVPPGL ; PSSVYPPSSG ; EDYGRDATAY ; 250: PSAKTPSSTY ; PAPFYVADGS ; LHPSAELWSP ; PGQAGFGPML ; GGGSSPLPLP ; 300: PGSGPVGSSG ; SSSTFGGLHQ ; HERMGYQLHG ; AEVNGGLPSA ; SSFSSAPGAT ; 350: YGGVSSHTPP ; VSGADSLLGS ; RGTTAGSSGD ; ALGKALASIY ; SPDHSSNNFS ; 400: SSPSTPVGSP ; QGLAGTSQWP ; RAGAPGALSP ; SYDGGLHGLQ ; SKIEDHLDEA ; 450: IHVLRSHAVG ; TAGDMHTLLP ; GHGALASGFT ; GPMSLGGRHA ; GLVGGSHPED ; 500: GLAGSTSLMH ; NHAALPSQPG ; TLPDLSRPPD ; SYSGLGRAGA ; TAAASEIKRE ; 550: EKEDEENTSA ; ADHSEEEKKE ; LKAPRARTSP ; DEDEDDLLPP ; EQKAEREKER ; 600: RVANNARERL ; RVRDINEAFK ; ELGRMCQLHL ; NSEKPQTKLL ; ILHQAVSVIL ; 650: NLEQQVRERN ; LNPKAACLKR ; REEEKVSGVV ; GDPQMVLSAP ; HPGLSEAHNP ; 654: AGHM
Sequence Length	654
String	P15923
Sub Unit	Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with RALGAPA1 and FIGLA. Efficient DNA binding requires dimerization with another bHLH protein. Component of a nuclear TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with NEUROD2, PTF1A and TGFB1I1 (By similarity). Homodimer. Heterodimer. Forms a heterodimer with NEUROD1; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300 and UBE2I.

Uniprot	P15923
Gene Name	TCF3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6929
Unigene	Hs.371282

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810220	E14975h	96T	$736		Add to Cart

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