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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transcription factor AP-1

SKU : BHE13805946

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1292h
Alternative Names	Activator protein 1 ; AP1 ; Proto-oncogene c-Jun ; V-jun avian sarcoma virus 17 oncogene homolog ; p39
Categories	Elisa
Function	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Specificity	Natural and recombinant Human Transcription factor AP-1
Subcellular Location	Nucleus
Detection Range	1.56-100ng/mL
Entryname	JUN_HUMAN
Method Type	Sandwich
Platform	PF00170
Protein Name	Transcription factor AP-1
Sensitivity	0.98ng/mL
Sequence	50: MTAKMETTFY ; DDALNASFLP ; SESGPYGYSN ; PKILKQSMTL ; NLADPVGSLK ; 100: PHLRAKNSDL ; LTSPDVGLLK ; LASPELERLI ; IQSSNGHITT ; TPTPTQFLCP ; 150: KNVTDEQEGF ; AEGFVRALAE ; LHSQNTLPSV ; TSAAQPVNGA ; GMVAPAVASV ; 200: AGGSGSGGFS ; ASLHSEPPVY ; ANLSNFNPGA ; LSSGGGAPSY ; GAAGLAFPAQ ; 250: PQQQQQPPHH ; LPQQMPVQHP ; RLQALKEEPQ ; TVPEMPGETP ; PLSPIDMESQ ; 300: ERIKAERKRM ; RNRIAASKCR ; KRKLERIARL ; EEKVKTLKAQ ; NSELASTANM ; 331: LREQVAQLKQ ; KVMNHVNSGC ; QLMLTQQLQT ; F
Sequence Length	331
String	P05412
Sub Unit	Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.

Uniprot	P05412
Gene Name	JUN
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3725
Unigene	Hs.696684

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805946	E1292h	96T	$736		Add to Cart

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