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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Transcription factor 7-like 2

SKU : BHE13808835

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5449h
Alternative Names	HMG box transcription factor 4 ; T-cell-specific transcription factor 4 ; T-cell factor 4 ; TCF4
Categories	Elisa
Function	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Specificity	Natural and recombinant Human Transcription factor 7-like 2
Subcellular Location	Nucleus PML body Diffuse patte. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Detection Range	78-5000pg/mL
Entryname	TF7L2_HUMAN
Method Type	Sandwich
Platform	PF08347
Protein Name	Transcription factor 7-like 2
Sensitivity	54pg/mL
Sequence	50: MPQLNGGGGD ; DLGANDELIS ; FKDEGEQEEK ; SSENSSAERD ; LADVKSSLVN ; 100: ESETNQNSSS ; DSEAERRPPP ; RSESFRDKSR ; ESLEEAAKRQ ; DGGLFKGPPY ; 150: PGYPFIMIPD ; LTSPYLPNGS ; LSPTARTLHF ; QSGSTHYSAY ; KTIEHQIAVQ ; 200: YLQMKWPLLD ; VQAGSLQSRQ ; ALKDARSPSP ; AHIVSNKVPV ; VQHPHHVHPL ; 250: TPLITYSNEH ; FTPGNPPPHL ; PADVDPKTGI ; PRPPHPPDIS ; PYYPLSPGTV ; 300: GQIPHPLGWL ; VPQQGQPVYP ; ITTGGFRHPY ; PTALTVNASM ; SRFPPHMVPP ; 350: HHTLHTTGIP ; HPAIVTPTVK ; QESSQSDVGS ; LHSSKHQDSK ; KEEEKKKPHI ; 400: KKPLNAFMLY ; MKEMRAKVVA ; ECTLKESAAI ; NQILGRRWHA ; LSREEQAKYY ; 450: ELARKERQLH ; MQLYPGWSAR ; DNYGKKKKRK ; RDKQPGETNE ; HSECFLNPCL ; 500: SLPPITDLSA ; PKKCRARFGL ; DQQNNWCGPC ; RRKKKCVRYI ; QGEGSCLSPP ; 550: SSDGSLLDSP ; PPSPNLLGSP ; PRDAKSQTEQ ; TQPLSLSLKP ; DPLAHLSMMP ; 600: PPPALLLAEA ; THKASALCPN ; GALDLPPAAL ; QPAAPSSSIA ; QPSTSSLHSH ; 619: SSLAGTQPQP ; LSLVTKSLE
Sequence Length	619
String	Q9NQB0
Sub Unit	Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promoters, negatively modulating its transcriptional activity.

Uniprot	Q9NQB0
Gene Name	TCF7L2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6934
Unigene	Hs.593995

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808835	E5449h	96T	$736		Add to Cart

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