ELISA Kit for Human Toll/interleukin-1 receptor domain-containing adapter protein

Mfr.No.	E4819h
Alternative Names	Adaptor protein Wyatt ; MyD88 adapter-like protein ; MyD88-2 ; MAL
Categories	Elisa
Function	Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Specificity	Natural and recombinant Human Toll/interleukin-1 receptor domain-containing adapter protein
Subcellular Location	Cytoplasm
Detection Range	31.2-2000pg/mL
Entryname	TIRAP_HUMAN
Method Type	Sandwich
Platform	PF01582
Protein Name	Toll/interleukin-1 receptor domain-containing adapter protein
Sensitivity	15pg/mL
Sequence	50: MASSTSLPAP ; GSRPKKPLGK ; MADWFRQTLL ; KKPKKRPNSP ; ESTSSDASQP ; 100: TSQDSPLPPS ; LSSVTSPSLP ; PTHASDSGSS ; RWSKDYDVCV ; CHSEEDLVAA ; 150: QDLVSYLEGS ; TASLRCFLQL ; RDATPGGAIV ; SELCQALSSS ; HCRVLLITPG ; 200: FLQDPWCKYQ ; MLQALTEAPG ; AEGCTIPLLS ; GLSRAAYPPE ; LRFMYYVDGR ; 221: GPDGGFRQVK ; EAVMRYLQTL ; S
Sequence Length	221
String	P58753
Sub Unit	Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to BMX, PKR and TBK1. Does not interact with IRAK1, nor TLR9.

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810926	E4819h	96T	$736		Add to Cart