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ELISA Kit for Human TNF receptor-associated factor 6

SKU : BHE13811303

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8869h
Alternative Names	E3 ubiquitin-protein ligase TRAF6 ; Interleukin-1 signal transducer ; RING finger protein 85 ; RING-type E3 ubiquitin transferase TRAF6 ; RNF85
Categories	Elisa
Function	E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor.
Specificity	Natural and recombinant Human TNF receptor-associated factor 6
Subcellular Location	Cytoplasm Cytoplasm cell cortex Nucleus Found in the nuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T-and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus.
Detection Range	0.156-10ng/mL
Entryname	TRAF6_HUMAN
Method Type	Sandwich
Platform	PF00917
Protein Name	TNF receptor-associated factor 6
Sensitivity	0.078ng/mL
Sequence	50: MSLLNCENSC ; GSSQSESDCC ; VAMASSCSAV ; TKDDSVGGTA ; STGNLSSSFM ; 100: EEIQGYDVEF ; DPPLESKYEC ; PICLMALREA ; VQTPCGHRFC ; KACIIKSIRD ; 150: AGHKCPVDNE ; ILLENQLFPD ; NFAKREILSL ; MVKCPNEGCL ; HKMELRHLED ; 200: HQAHCEFALM ; DCPQCQRPFQ ; KFHINIHILK ; DCPRRQVSCD ; NCAASMAFED ; 250: KEIHDQNCPL ; ANVICEYCNT ; ILIREQMPNH ; YDLDCPTAPI ; PCTFSTFGCH ; 300: EKMQRNHLAR ; HLQENTQSHM ; RMLAQAVHSL ; SVIPDSGYIS ; EVRNFQETIH ; 350: QLEGRLVRQD ; HQIRELTAKM ; ETQSMYVSEL ; KRTIRTLEDK ; VAEIEAQQCN ; 400: GIYIWKIGNF ; GMHLKCQEEE ; KPVVIHSPGF ; YTGKPGYKLC ; MRLHLQLPTA ; 450: QRCANYISLF ; VHTMQGEYDS ; HLPWPFQGTI ; RLTILDQSEA ; PVRQNHEEIM ; 500: DAKPELLAFQ ; RPTIPRNPKG ; FGYVTFMHLE ; ALRQRTFIKD ; DTLLVRCEVS ; 522: TRFDMGSLRR ; EGFQPRSTDA ; GV
Sequence Length	522
String	Q9Y4K3
Sub Unit	Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with JUB. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1.

Uniprot	Q9Y4K3
Gene Name	TRAF6
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7189
Unigene	Hs.444172

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811303	E8869h	96T	$736		Add to Cart

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