Gene associated with retinoic and interferon-induced mortality 12 protein ; GRIM-12 ; KM-102-derived reductase-like factor ; Thioredoxin reductase TR1 ; GRIM12 ; KDRF
Categories
Elisa
Function
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Specificity
Natural and recombinant Human Thioredoxin reductase 1, cytoplasmic