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Home / Assay Kits / ELISA Kits

ELISA Kit for Human TGF-beta receptor type-2

SKU : BHE13811360

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9935h
Alternative Names	TGF-beta type II receptor ; Transforming growth factor-beta receptor type II ; TGF-beta receptor type II
Categories	Elisa
Function	Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Specificity	Natural and recombinant Human TGF-beta receptor type-2
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/mL
Entryname	TGFR2_HUMAN
Method Type	Sandwich
Platform	PF08917
Protein Name	TGF-beta receptor type-2
Sensitivity	0.067ng/mL
Sequence	50: MGRGLLRGLW ; PLHIVLWTRI ; ASTIPPHVQK ; SVNNDMIVTD ; NNGAVKFPQL ; 100: CKFCDVRFST ; CDNQKSCMSN ; CSITSICEKP ; QEVCVAVWRK ; NDENITLETV ; 150: CHDPKLPYHD ; FILEDAASPK ; CIMKEKKKPG ; ETFFMCSCSS ; DECNDNIIFS ; 200: EEYNTSNPDL ; LLVIFQVTGI ; SLLPPLGVAI ; SVIIIFYCYR ; VNRQQKLSST ; 250: WETGKTRKLM ; EFSEHCAIIL ; EDDRSDISST ; CANNINHNTE ; LLPIELDTLV ; 300: GKGRFAEVYK ; AKLKQNTSEQ ; FETVAVKIFP ; YEEYASWKTE ; KDIFSDINLK ; 350: HENILQFLTA ; EERKTELGKQ ; YWLITAFHAK ; GNLQEYLTRH ; VISWEDLRKL ; 400: GSSLARGIAH ; LHSDHTPCGR ; PKMPIVHRDL ; KSSNILVKND ; LTCCLCDFGL ; 450: SLRLDPTLSV ; DDLANSGQVG ; TARYMAPEVL ; ESRMNLENVE ; SFKQTDVYSM ; 500: ALVLWEMTSR ; CNAVGEVKDY ; EPPFGSKVRE ; HPCVESMKDN ; VLRDRGRPEI ; 550: PSFWLNHQGI ; QMVCETLTEC ; WDHDPEARLT ; AQCVAERFSE ; LEHLDRLSGR ; 567: SCSEEKIPED ; GSLNTTK
Sequence Length	567
String	P37173
Sub Unit	Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX. Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor.

Uniprot	P37173
Gene Name	TGFBR2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7048
Unigene	Hs.604277

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811360	E9935h	96T	$736		Add to Cart

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