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ELISA Kit for Human Suppressor of cytokine signaling 3

SKU : BHE13810892

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1684h
Alternative Names	Cytokine-inducible SH2 protein 3 ; CIS-3 ; STAT-induced STAT inhibitor 3 ; SSI-3 ; CIS3 ; SSI3
Categories	Elisa
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
Specificity	Natural and recombinant Human Suppressor of cytokine signaling 3
Detection Range	31.2-2000pg/mL
Entryname	SOCS3_HUMAN
Method Type	Sandwich
Platform	PF00017
Protein Name	Suppressor of cytokine signaling 3
Sensitivity	23pg/mL
Sequence	50: MVTHSKFPAA ; GMSRPLDTSL ; RLKTFSSKSE ; YQLVVNAVRK ; LQESGFYWSA ; 100: VTGGEANLLL ; SAEPAGTFLI ; RDSSDQRHFF ; TLSVKTQSGT ; KNLRIQCEGG ; 150: SFSLQSDPRS ; TQPVPRFDCV ; LKLVHHYMPP ; PGAPSFPSPP ; TEPSSEVPEQ ; 200: PSAQPLPGSP ; PRRAYYIYSG ; GEKIPLVLSR ; PLSSNVATLQ ; HLCRKTVNGH ; 225: LDSYEKVTQL ; PGPIREFLDQ ; YDAPL
Sequence Length	225
String	O14543
Sub Unit	Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3.

Uniprot	O14543
Gene Name	SOCS3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9021
Unigene	Hs.527973

Reference	1. "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3." Minamoto S., Ikegame K., Ueno K., Narazaki M., Naka T., Yamamoto H., Matsumoto T., Saito H., Hosoe S., Kishimoto T. Biochem. Biophys. Res. Commun.237:79-83(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT TYR-125 tissue: T-cell lymphoma. 2. "Cloning and characterization of novel CIS family genes." Masuhara M., Sakamoto H., Matsumoto A., Suzuki R., Yasukawa H., Mitsui K., Wakioka T., Tanimura S., Sasaki A., Misawa H., Yokouchi M., Ohtsubo M., Yoshimura A. Biochem. Biophys. Res. Commun.239:439-446(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 3. "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor." Dey B.R., Furlanetto R.W., Nissley P. Biochem. Biophys. Res. Commun.278:38-43(2000) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] tissue: Skeletal muscle. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Placenta. 5. "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain." Sasaki A., Yasukawa H., Suzuki A., Kamizono S., Syoda T., Kinjyo I., Sasaki M., Johnston J.A., Yoshimura A. Genes Cells4:339-351(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAK2;MUTAGENESIS OF LEU-22; PHE-25; GLU-30; TYR-31; VAL-34; LEU-41; GLY-45 AND ARG-71 6. "A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor." Hoertner M., Nielsch U., Mayr L.M., Heinrich P.C., Haan S. Eur. J. Biochem.269:2516-2526(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPOR;MUTAGENESIS OF GLY-53; LEU-58; LEU-93 AND ARG-94 7. "SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit." Yamamoto K., Yamaguchi M., Miyasaka N., Miura O. Biochem. Biophys. Res. Commun.310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL12RB2;MUTAGENESIS OF ARG-71 8. "Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation." Okamura A., Iwata N., Nagata A., Tamekane A., Shimoyama M., Gomyo H., Yakushijin K., Urahama N., Hamaguchi M., Fukui C., Chihara K., Ito M., Matsui T. Blood103:2997-3004(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK1E;PROTEIN STABILIZATION 9. "VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases." Kamura T., Maenaka K., Kotoshiba S., Matsumoto M., Kohda D., Conaway R.C., Conaway J.W., Nakayama K.I. Genes Dev.18:3055-3065(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AN E3 UBIQUITIN-PROTEIN LIGASE COMPLEX;INTERACTION WITH CUL5; RNF7; TCEB1 AND TCEB2 10. "Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis." Ekelund E., Saeaef A., Tengvall-Linder M., Melen E., Link J., Barker J., Reynolds N.J., Meggitt S.J., Kere J., Wahlgren C.-F., Pershagen G., Wickman M., Nordenskjoeld M., Kockum I., Bradley M. Am. J. Hum. Genet.78:1060-1065(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ATOPIC DERMATITIS 11. "Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling." Ben-Zvi T., Yayon A., Gertler A., Monsonego-Ornan E. J. Cell Sci.119:380-387(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR3

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