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Home / Assay Kits / ELISA Kits

ELISA Kit for Human SUMO-conjugating enzyme UBC9

SKU : BHE13811508

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11134h
Alternative Names	RING-type E3 SUMO transferase UBC9 ; SUMO-protein ligase ; Ubiquitin carrier protein 9 ; Ubiquitin carrier protein I ; Ubiquitin-conjugating enzyme E2 I ; Ubiquitin-protein ligase I ; p18 ; UBC9 ; UBCE9
Categories	Elisa
Function	Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation.
Specificity	Natural and recombinant Human SUMO-conjugating enzyme UBC9
Subcellular Location	Nucleus Cytoplasm Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body.
Detection Range	0.156-10ng/mL
Entryname	UBC9_HUMAN
Method Type	Sandwich
Platform	PF00179
Protein Name	SUMO-conjugating enzyme UBC9
Sensitivity	0.078ng/ml
Sequence	50: MSGIALSRLA ; QERKAWRKDH ; PFGFVAVPTK ; NPDGTMNLMN ; WECAIPGKKG ; 100: TPWEGGLFKL ; RMLFKDDYPS ; SPPKCKFEPP ; LFHPNVYPSG ; TVCLSILEED ; 150: KDWRPAITIK ; QILLGIQELL ; NEPNIQDPAQ ; AEAYTIYCQN ; RVEYEKRVRA ; 158: QAKKFAPS
Sequence Length	158
String	P63279
Sub Unit	Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains.

Uniprot	P63279
Gene Name	UBE2I
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:7329
Unigene	Hs.302903

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811508	E11134h	96T	$736		Add to Cart

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