Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
Specificity
Natural and recombinant Human Sphingosine-1-phosphate lyase 1
Subcellular Location
Endoplasmic reticulum membrane Single-pass type III membrane protein