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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Sorting nexin-1

SKU : BHE13810589

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15090h
Categories	Elisa
Function	May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Specificity	Natural and recombinant Human Sorting nexin-1
Subcellular Location	Endosome membrane Peripheral membrane protein Cytoplasmic side Golgi apparatus trans-Golgi network membrane Peripheral membrane protein Cytoplasmic side Early endosome membrane Peripheral membrane protein Cytoplasmic side Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIn.
Detection Range	78-5000pg/mL
Entryname	SNX1_HUMAN
Method Type	Sandwich
Platform	PF00787
Protein Name	Sorting nexin-1
Sensitivity	35pg/ml
Sequence	50: MASGGGGCSA ; SERLPPPFPG ; LEPESEGAAG ; GSEPEAGDSD ; TEGEDIFTGA ; 100: AVVSKHQSPK ; ITTSLLPINN ; GSKENGIHEE ; QDQEPQDLFA ; DATVELSLDS ; 150: TQNNQKKVLA ; KTLISLPPQE ; ATNSSKPQPT ; YEELEEEEQE ; DQFDLTVGIT ; 200: DPEKIGDGMN ; AYVAYKVTTQ ; TSLPLFRSKQ ; FAVKRRFSDF ; LGLYEKLSEK ; 250: HSQNGFIVPP ; PPEKSLIGMT ; KVKVGKEDSS ; SAEFLEKRRA ; ALERYLQRIV ; 300: NHPTMLQDPD ; VREFLEKEEL ; PRAVGTQTLS ; GAGLLKMFNK ; ATDAVSKMTI ; 350: KMNESDIWFE ; EKLQEVECEE ; QRLRKLHAVV ; ETLVNHRKEL ; ALNTAQFAKS ; 400: LAMLGSSEDN ; TALSRALSQL ; AEVEEKIEQL ; HQEQANNDFF ; LLAELLSDYI ; 450: RLLAIVRAAF ; DQRMKTWQRW ; QDAQATLQKK ; REAEARLLWA ; NKPDKLQQAK ; 500: DEILEWESRV ; TQYERDFERI ; STVVRKEVIR ; FEKEKSKDFK ; NHVIKYLETL ; 522: LYSQQQLAKY ; WEAFLPEAKA ; IS
Sequence Length	522
String	Q13596
Sub Unit	Homodimer. Self-assembles into a complex of approximately 300 kDa (By similarity). Interacts with HGS (By similarity). Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with SNX6.

Uniprot	Q13596
Gene Name	SNX1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6642
Unigene	Hs.188634

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810589	E15090h	96T	$736		Add to Cart

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