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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Sorbin and SH3 domain-containing protein 1

SKU : BHE13811046

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3361h
Alternative Names	Ponsin ; SH3 domain protein 5 ; SH3P12 ; c-Cbl-associated protein ; CAP ; KIAA0894 ; KIAA1296 ; SH3D5
Categories	Elisa
Function	Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Specificity	Natural and recombinant Human Sorbin and SH3 domain-containing protein 1
Subcellular Location	Cell junction adherens junction Cell membrane Cytoplasm cytoskeleton Cell junction focal adhesion Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.
Detection Range	0.312-20ng/ml
Entryname	SRBS1_HUMAN
Method Type	Sandwich
Platform	PF07653
Protein Name	Sorbin and SH3 domain-containing protein 1
Sensitivity	0.12ng/mL
Sequence	50: MSSECDGGSK ; AVMNGLAPGS ; NGQDKATADP ; LRARSISAVK ; IIPVKTVKNA ; 100: SGLVLPTDMD ; LTKICTGKGA ; VTLRASSSYR ; ETPSSSPASP ; QETRQHESKP ; 150: GLEPEPSSAD ; EWRLSSSADA ; NGNAQPSSLA ; AKGYRSVHPN ; LPSDKSQDAT ; 200: SSSAAQPEVI ; VVPLYLVNTD ; RGQEGTARPP ; TPLGPLGCVP ; TIPATASAAS ; 250: PLTFPTLDDF ; IPPHLQRWPH ; HSQPARASGS ; FAPISQTPPS ; FSPPPPLVPP ; 300: APEDLRRVSE ; PDLTGAVSST ; DSSPLLNEVS ; SSLIGTDSQA ; FPSVSKPSSA ; 350: YPSTTIVNPT ; IVLLQHNREQ ; QKRLSSLSDP ; VSERRVGEQD ; SAPTQEKPTS ; 400: PGKAIEKRAK ; DDSRRVVKST ; QDLSDVSMDE ; VGIPLRNTER ; SKDWYKTMFK ; 450: QIHKLNRDTP ; EENPYFPTYK ; FPELPEIQQT ; SEEDNPYTPT ; YQFPASTPSP ; 500: KSEDDDSDLY ; SPRYSFSEDT ; KSPLSVPRSK ; SEMSYIDGEK ; VVKRSATLPL ; 550: PARSSSLKSS ; SERNDWEPPD ; KKVDTRKYRA ; EPKSIYEYQP ; GKSSVLTNEK ; 600: MSRDISPEEI ; DLKNEPWYKF ; FSELEFGKPP ; PKKIWDYTPG ; DCSILPREDR ; 650: KTNLDKDLSL ; CQTELEADLE ; KMETLNKAPS ; ANVPQSSAIS ; PTPEISSETP ; 700: GYIYSSNFHA ; VKRESDGAPG ; DLTSLENERQ ; IYKSVLEGGD ; IPLQGLSGLK ; 750: RPSSSASTKD ; SESPRHFIPA ; DYLESTEEFI ; RRRHDDKEKL ; LADQRRLKRE ; 800: QEEADIAARR ; HTGVIPTHHQ ; FITNERFGDL ; LNIDDTAKRK ; SGSEMRPARA ; 850: KFDFKAQTLK ; ELPLQKGDIV ; YIYKQIDQNW ; YEGEHHGRVG ; IFPRTYIELL ; 900: PPAEKAQPKK ; LTPVQVLEYG ; EAIAKFNFNG ; DTQVEMSFRK ; GERITLLRQV ; 950: DENWYEGRIP ; GTSRQGIFPI ; TYVDVIKRPL ; VKNPVDYMDL ; PFSSSPSRSA ; 1000: TASPQFSSHS ; KLITPAPSSL ; PHSRRALSPE ; MHAVTSEWIS ; LTVGVPGRRS ; 1050: LALTPPLPPL ; PEASIYNTDH ; LALSPRASPS ; LSLSLPHLSW ; SDRPTPRSVA ; 1100: SPLALPSPHK ; TYSLAPTSQA ; SLHMNGDGGV ; HTPSSGIHQD ; SFLQLPLGSS ; 1150: DSVISQLSDA ; FSSQSKRQPW ; REESGQYERK ; AERGAGERGP ; GGPKISKKSC ; 1200: LKPSDVVRCL ; STEQRLSDLN ; TPEESRPGKP ; LGSAFPGSEA ; EQTERHRGGE ; 1250: QAGRKAARRG ; GSQQPQAQQR ; RVTPDRSQTS ; QDLFSYQALY ; SYIPQNDDEL ; 1292: ELRDGDIVDV ; MEKCDDGWFV ; GTSRRTKQFG ; TFPGNYVKPL ; YL
Sequence Length	1292
String	Q9BX66
Sub Unit	Interacts with the long isoform of MLLT4/afadin and with VCL. MLLT4 and VCL bind to SORBS1 in a competitive manner and do not form a ternary complex. Interacts with ABL1, CBL, CBLB and INPPL1/SHIP2 through the third SH3 domain. Interaction with ABL1 occurs only after insulin stimulation while this has no effect on the interaction with INPPL1. Interacts with the insulin receptor but dissociates from it following insulin stimulation. Also interacts with SCA7, PTK2/p125FAK and flotillin. Interacts (via SH3 domain 2) with PXN.

Uniprot	Q9BX66
Gene Name	SORBS1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:10580
Unigene	Hs.38621

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811046	E3361h	96T	$736		Add to Cart

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