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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Sonic hedgehog protein

SKU : BHE13810154

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1831h
Alternative Names	HHG-1
Categories	Elisa
Function	Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction.
Specificity	Natural and recombinant Human Sonic hedgehog protein
Subcellular Location	Sonic hedgehog protein N-product Cell membrane Lipid-anchor The N-product either remains associated with lipid rafts at the cell surface, or forms freely diffusible active multimers with its hydrophobic lipid-modified N- and C-termini buried inside.
Detection Range	78-5000pg/ml
Entryname	SHH_HUMAN
Method Type	Sandwich
Platform	PF01085
Protein Name	Sonic hedgehog protein
Sensitivity	10pg/mL
Sequence	50: MLLLARCLLL ; VLVSSLLVCS ; GLACGPGRGF ; GKRRHPKKLT ; PLAYKQFIPN ; 100: VAEKTLGASG ; RYEGKISRNS ; ERFKELTPNY ; NPDIIFKDEE ; NTGADRLMTQ ; 150: RCKDKLNALA ; ISVMNQWPGV ; KLRVTEGWDE ; DGHHSEESLH ; YEGRAVDITT ; 200: SDRDRSKYGM ; LARLAVEAGF ; DWVYYESKAH ; IHCSVKAENS ; VAAKSGGCFP ; 250: GSATVHLEQG ; GTKLVKDLSP ; GDRVLAADDQ ; GRLLYSDFLT ; FLDRDDGAKK ; 300: VFYVIETREP ; RERLLLTAAH ; LLFVAPHNDS ; ATGEPEASSG ; SGPPSGGALG ; 350: PRALFASRVR ; PGQRVYVVAE ; RDGDRRLLPA ; AVHSVTLSEE ; AAGAYAPLTA ; 400: QGTILINRVL ; ASCYAVIEEH ; SWAHRAFAPF ; RLAHALLAAL ; APARTDRGGD ; 450: SGGGDRGGGG ; GRVALTAPGA ; ADAPGAGATA ; GIHWYSQLLY ; QIGTWLLDSE ; 462: ALHPLGMAVK ; SS
Sequence Length	462
String	Q15465
Sub Unit	Interacts with HHATL/GUP1 which negatively regulates HHAT-mediated palmitoylation of the SHH N-terminus. N-product is active as a multimer.

Uniprot	Q15465
Gene Name	SHH
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6469
Unigene	Hs.164537

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810154	E1831h	96T	$536		Add to Cart

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