Neuroendocrine sodium channel ; hNE-Na ; Peripheral sodium channel 1 ; PN1 ; Sodium channel protein type IX subunit alpha ; Voltage-gated sodium channel subunit alpha Nav1.7 ; NENA
Categories
Elisa
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Specificity
Natural and recombinant Human Sodium channel protein type 9 subunit alpha
Subcellular Location
Membrane Multi-pass membrane protein In neurite terminals.
The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L.