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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Signal transducer and activator of transcription 4

SKU : BHE13810753

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1739h
Categories	Elisa
Function	Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Specificity	Natural and recombinant Human Signal transducer and activator of transcription 4
Subcellular Location	Cytoplasm Nucleus Translocated into the nucleus in response to phosphorylation.
Detection Range	0.312-20ng/mL
Entryname	STAT4_HUMAN
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 4
Sensitivity	0.168ng/mL
Sequence	50: MSQWNQVQQL ; EIKFLEQVDQ ; FYDDNFPMEI ; RHLLAQWIEN ; QDWEAASNNE ; 100: TMATILLQNL ; LIQLDEQLGR ; VSKEKNLLLI ; HNLKRIRKVL ; QGKFHGNPMH ; 150: VAVVISNCLR ; EERRILAAAN ; MPVQGPLEKS ; LQSSSVSERQ ; RNVEHKVAAI ; 200: KNSVQMTEQD ; TKYLEDLQDE ; FDYRYKTIQT ; MDQSDKNSAM ; VNQEVLTLQE ; 250: MLNSLDFKRK ; EALSKMTQII ; HETDLLMNTM ; LIEELQDWKR ; RQQIACIGGP ; 300: LHNGLDQLQN ; CFTLLAESLF ; QLRRQLEKLE ; EQSTKMTYEG ; DPIPMQRTHM ; 350: LERVTFLIYN ; LFKNSFVVER ; QPCMPTHPQR ; PLVLKTLIQF ; TVKLRLLIKL ; 400: PELNYQVKVK ; ASIDKNVSTL ; SNRRFVLCGT ; NVKAMSIEES ; SNGSLSVEFR ; 450: HLQPKEMKSS ; AGGKGNEGCH ; MVTEELHSIT ; FETQICLYGL ; TIDLETSSLP ; 500: VVMISNVSQL ; PNAWASIIWY ; NVSTNDSQNL ; VFFNNPPPAT ; LSQLLEVMSW ; 550: QFSSYVGRGL ; NSDQLHMLAE ; KLTVQSSYSD ; GHLTWAKFCK ; EHLPGKSFTF ; 600: WTWLEAILDL ; IKKHILPLWI ; DGYVMGFVSK ; EKERLLLKDK ; MPGTFLLRFS ; 650: ESHLGGITFT ; WVDHSESGEV ; RFHSVEPYNK ; GRLSALPFAD ; ILRDYKVIMA ; 700: ENIPENPLKY ; LYPDIPKDKA ; FGKHYSSQPC ; EVSRPTERGD ; KGYVPSVFIP ; 748: ISTIRSDSTE ; PHSPSDLLPM ; SPSVYAVLRE ; NLSPTTIETA ; MKSPYSAE
Sequence Length	748
String	Q14765
Sub Unit	Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

Uniprot	Q14765
Gene Name	STAT4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6775
Unigene	Hs.80642

Reference	1. "The STAT amino-terminal domain mediates cooperative DNA binding and confers selective sequence recognition." Xu X., Sun Y.L., Hoey T. Submitted (1996-08) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] 2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] tissue: Testis. 3. SeattleSNPs variation discovery resource Submitted (2001-09) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-748 4. "Direct interaction of STAT4 with the IL-12 receptor." Yao B.B., Niu P., Surowy C.S., Faltynek C.R. Arch. Biochem. Biophys.368:147-155(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL12RB2 5. "Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling." Naeger L.K., McKinney J., Salvekar A., Hoey T. J. Biol. Chem.274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL12RB2 6. "Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo." Kariuki S.N., Kirou K.A., MacDermott E.J., Barillas-Arias L., Crow M.K., Niewold T.B. J. Immunol.182:34-38(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLEB11 7. "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.more... Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-112 8. "STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus." Remmers E.F., Plenge R.M., Lee A.T., Graham R.R., Hom G., Behrens T.W., de Bakker P.I.W., Le J.M., Lee H.-S., Batliwalla F., Li W., Masters S.L., Booty M.G., Carulli J.P., Padyukov L., Alfredsson L., Klareskog L., Chen W.V., Amos C.I., Criswell L.A., Seldin M.F., Kastner D.L., Gregersen P.K.more... N. Engl. J. Med.357:977-986(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLEB11 AND RA

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