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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Signal transducer and activator of transcription 2

SKU : BHE13809575

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1796h
Alternative Names	p113
Categories	Elisa
Function	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Specificity	Natural and recombinant Human Signal transducer and activator of transcription 2
Subcellular Location	Cytoplasm Nucleus Translocated into the nucleus upon activation by IFN-alpha/beta.
Detection Range	78-5000pg/mL
Entryname	STAT2_HUMAN
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 2
Sensitivity	40.1pg/mL
Sequence	50: MAQWEMLQNL ; DSPFQDQLHQ ; LYSHSLLPVD ; IRQYLAVWIE ; DQNWQEAALG ; 100: SDDSKATMLF ; FHFLDQLNYE ; CGRCSQDPES ; LLLQHNLRKF ; CRDIQPFSQD ; 150: PTQLAEMIFN ; LLLEEKRILI ; QAQRAQLEQG ; EPVLETPVES ; QQHEIESRIL ; 200: DLRAMMEKLV ; KSISQLKDQQ ; DVFCFRYKIQ ; AKGKTPSLDP ; HQTKEQKILQ ; 250: ETLNELDKRR ; KEVLDASKAL ; LGRLTTLIEL ; LLPKLEEWKA ; QQQKACIRAP ; 300: IDHGLEQLET ; WFTAGAKLLF ; HLRQLLKELK ; GLSCLVSYQD ; DPLTKGVDLR ; 350: NAQVTELLQR ; LLHRAFVVET ; QPCMPQTPHR ; PLILKTGSKF ; TVRTRLLVRL ; 400: QEGNESLTVE ; VSIDRNPPQL ; QGFRKFNILT ; SNQKTLTPEK ; GQSQGLIWDF ; 450: GYLTLVEQRS ; GGSGKGSNKG ; PLGVTEELHI ; ISFTVKYTYQ ; GLKQELKTDT ; 500: LPVVIISNMN ; QLSIAWASVL ; WFNLLSPNLQ ; NQQFFSNPPK ; APWSLLGPAL ; 550: SWQFSSYVGR ; GLNSDQLSML ; RNKLFGQNCR ; TEDPLLSWAD ; FTKRESPPGK ; 600: LPFWTWLDKI ; LELVHDHLKD ; LWNDGRIMGF ; VSRSQERRLL ; KKTMSGTFLL ; 650: RFSESSEGGI ; TCSWVEHQDD ; DKVLIYSVQP ; YTKEVLQSLP ; LTEIIRHYQL ; 700: LTEENIPENP ; LRFLYPRIPR ; DEAFGCYYQE ; KVNLQERRKY ; LKHRLIVVSN ; 750: RQVDELQQPL ; ELKPEPELES ; LELELGLVPE ; PELSLDLEPL ; LKAGLDLGPE ; 800: LESVLESTLE ; PVIEPTLCMV ; SQTVPEPDQG ; PVSQPVPEPD ; LPCDLRHLNT ; 850: EPMEIFRNCV ; KIEEIMPNGD ; PLLAGQNTVD ; EVYVSRPSHF ; YTDGPLMPSD ; 851: F
Sequence Length	851
String	P52630
Sub Unit	Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity). Can form a homodimer upon IFN-alpha induced phosphorylation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with dengue virus NS5; this interaction inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation.

Uniprot	P52630
Gene Name	STAT2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6773
Unigene	Hs.530595

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809575	E1796h	96T	$536		Add to Cart

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