JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Signal transducer and activator of transcription 1-alpha/beta

SKU : BHE13809948

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E1740h
Alternative Names	Transcription factor ISGF-3 components p91/p84
Categories	Elisa
Function	Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Specificity	Natural and recombinant Human Signal transducer and activator of transcription 1-alpha/beta
Subcellular Location	Cytoplasm Nucleus Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4.
Detection Range	31.2-2000pg/mL
Entryname	STAT1_HUMAN
Method Type	Sandwich
Platform	PF00017
Protein Name	Signal transducer and activator of transcription 1-alpha/beta
Sensitivity	15.61pg/mL
Sequence	50: MSQWYELQQL ; DSKFLEQVHQ ; LYDDSFPMEI ; RQYLAQWLEK ; QDWEHAANDV ; 100: SFATIRFHDL ; LSQLDDQYSR ; FSLENNFLLQ ; HNIRKSKRNL ; QDNFQEDPIQ ; 150: MSMIIYSCLK ; EERKILENAQ ; RFNQAQSGNI ; QSTVMLDKQK ; ELDSKVRNVK ; 200: DKVMCIEHEI ; KSLEDLQDEY ; DFKCKTLQNR ; EHETNGVAKS ; DQKQEQLLLK ; 250: KMYLMLDNKR ; KEVVHKIIEL ; LNVTELTQNA ; LINDELVEWK ; RRQQSACIGG ; 300: PPNACLDQLQ ; NWFTIVAESL ; QQVRQQLKKL ; EELEQKYTYE ; HDPITKNKQV ; 350: LWDRTFSLFQ ; QLIQSSFVVE ; RQPCMPTHPQ ; RPLVLKTGVQ ; FTVKLRLLVK ; 400: LQELNYNLKV ; KVLFDKDVNE ; RNTVKGFRKF ; NILGTHTKVM ; NMEESTNGSL ; 450: AAEFRHLQLK ; EQKNAGTRTN ; EGPLIVTEEL ; HSLSFETQLC ; QPGLVIDLET ; 500: TSLPVVVISN ; VSQLPSGWAS ; ILWYNMLVAE ; PRNLSFFLTP ; PCARWAQLSE ; 550: VLSWQFSSVT ; KRGLNVDQLN ; MLGEKLLGPN ; ASPDGLIPWT ; RFCKENINDK ; 600: NFPFWLWIES ; ILELIKKHLL ; PLWNDGCIMG ; FISKERERAL ; LKDQQPGTFL ; 650: LRFSESSREG ; AITFTWVERS ; QNGGEPDFHA ; VEPYTKKELS ; AVTFPDIIRN ; 700: YKVMAAENIP ; ENPLKYLYPN ; IDKDHAFGKY ; YSRPKEAPEP ; MELDGPKGTG ; 750:
Sequence Length	750
String	P42224
Sub Unit	Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C', C, Y1 and Y2 proteins, Nipah virus P, V and W proteins, and rabies virus phosphoprotein preventing activation of ISRE and GAS promoter (By similarity). Interacts with HCV core protein; the interaction results in STAT1 degradation. Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation. Interacts with IFNAR1; the interaction requires the phosphorylation of IFNAR1 at 'Tyr-466'. Interacts with IFNAR2. Interacts with PIAS1 (dimethylated on arginine); the interaction results in release of STAT1 from its target gene.

Uniprot	P42224
Gene Name	STAT1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6772
Unigene	Hs.642990

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13809948	E1740h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.