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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase PLK1

SKU : BHE13808851

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1662h
Alternative Names	Polo-like kinase 1 ; PLK-1 ; Serine/threonine-protein kinase 13 ; STPK13 ; PLK
Categories	Elisa
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Phosphorylates NEDD1. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase PLK1
Subcellular Location	Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization.
Detection Range	7.8-500pg/mL
Entryname	PLK1_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase PLK1
Sensitivity	3.4pg/mL
Sequence	50: MSAAVTAGKL ; ARAPADPGKA ; GVPGVAAPGA ; PAAAPPAKEI ; PEVLVDPRSR ; 100: RRYVRGRFLG ; KGGFAKCFEI ; SDADTKEVFA ; GKIVPKSLLL ; KPHQREKMSM ; 150: EISIHRSLAH ; QHVVGFHGFF ; EDNDFVFVVL ; ELCRRRSLLE ; LHKRRKALTE ; 200: PEARYYLRQI ; VLGCQYLHRN ; RVIHRDLKLG ; NLFLNEDLEV ; KIGDFGLATK ; 250: VEYDGERKKT ; LCGTPNYIAP ; EVLSKKGHSF ; EVDVWSIGCI ; MYTLLVGKPP ; 300: FETSCLKETY ; LRIKKNEYSI ; PKHINPVAAS ; LIQKMLQTDP ; TARPTINELL ; 350: NDEFFTSGYI ; PARLPITCLT ; IPPRFSIAPS ; SLDPSNRKPL ; TVLNKGLENP ; 400: LPERPREKEE ; PVVRETGEVV ; DCHLSDMLQQ ; LHSVNASKPS ; ERGLVRQEEA ; 450: EDPACIPIFW ; VSKWVDYSDK ; YGLGYQLCDN ; SVGVLFNDST ; RLILYNDGDS ; 500: LQYIERDGTE ; SYLTVSSHPN ; SLMKKITLLK ; YFRNYMSEHL ; LKAGANITPR ; 550: EGDELARLPY ; LRTWFRTRSA ; IILHLSNGSV ; QINFFQDHTK ; LILCPLMAAV ; 600: TYIDEKRDFR ; TYRLSLLEEY ; GCCKELASRL ; RYARTMVDKL ; LSSRSASNRL ; 603: KAS
Sequence Length	603
String	P53350
Sub Unit	Interacts with CEP170 and EVI5. Interacts and phosphorylates ERCC6L. Interacts with FAM29A. Interacts with SLX4/BTBD12 and TTDN1. Interacts with BUB1B. Interacts (via POLO-box domain) with the phosphorylated form of BUB1, MLF1IP and CDC25C. Interacts with isoform 3 of SGOL1. Interacts with BORA, KIF2A and AURKA. Interacts with TOPORS and CYLD.

Uniprot	P53350
Gene Name	PLK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5347
Unigene	Hs.592049

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808851	E1662h	96T	$736		Add to Cart

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