Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
Specificity
Natural and recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial
Subcellular Location
Mitochondrion outer membrane Single-pass membrane protein Cytoplasm cytosol