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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase pim-2

SKU : BHE13808185

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5627h
Alternative Names	Pim-2h
Categories	Elisa
Function	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerced by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase pim-2
Detection Range	0.78-50ng/mL
Entryname	PIM2_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase pim-2
Sensitivity	0.39ng/mL
Sequence	50: MLTKPLQGPP ; APPGTPTPPP ; GGKDREAFEA ; EYRLGPLLGK ; GGFGTVFAGH ; 100: RLTDRLQVAI ; KVIPRNRVLG ; WSPLSDSVTC ; PLEVALLWKV ; GAGGGHPGVI ; 150: RLLDWFETQE ; GFMLVLERPL ; PAQDLFDYIT ; EKGPLGEGPS ; RCFFGQVVAA ; 200: IQHCHSRGVV ; HRDIKDENIL ; IDLRRGCAKL ; IDFGSGALLH ; DEPYTDFDGT ; 250: RVYSPPEWIS ; RHQYHALPAT ; VWSLGILLYD ; MVCGDIPFER ; DQEILEAELH ; 300: FPAHVSPDCC ; ALIRRCLAPK ; PSSRPSLEEI ; LLDPWMQTPA ; EDVPLNPSKG ; 311: GPAPLAWSLL ; P
Sequence Length	311
String	Q9P1W9
Sub Unit	Interacts with MYC.

Uniprot	Q9P1W9
Gene Name	PIM2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:11040
Unigene	Hs.726382

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808185	E5627h	96T	$736		Add to Cart

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