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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase LATS2

SKU : BHE13806408

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14088h
Alternative Names	Kinase phosphorylated during mitosis protein ; Large tumor suppressor homolog 2 ; Serine/threonine-protein kinase kpm ; Warts-like kinase ; KPM
Categories	Elisa
Function	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in tu phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase LATS2
Subcellular Location	Cytoplasm cytoskeleton centrosome Cytoplasm Cytoplasm cytoskeleton spindle pole Co-localizes with AURKA at the centrosomes during interphase, early prophase and cytokinesis. Migrates to the spindle poles during mitosis, and to the midbody during cytokinesis.
Detection Range	78-5000pg/mL
Entryname	LATS2_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase LATS2
Sensitivity	36pg/mL
Sequence	50: MRPKTFPATT ; YSGNSRQRLQ ; EIREGLKQPS ; KSSVQGLPAG ; PNSDTSLDAK ; 100: VLGSKDATRQ ; QQQMRATPKF ; GPYQKALREI ; RYSLLPFANE ; SGTSAAAEVN ; 150: RQMLQELVNA ; GCDQEMAGRA ; LKQTGSRSIE ; AALEYISKMG ; YLDPRNEQIV ; 200: RVIKQTSPGK ; GLMPTPVTRR ; PSFEGTGDSF ; ASYHQLSGTP ; YEGPSFGADG ; 250: PTALEEMPRP ; YVDYLFPGVG ; PHGPGHQHQH ; PPKGYGASVE ; AAGAHFPLQG ; 300: AHYGRPHLLV ; PGEPLGYGVQ ; RSPSFQSKTP ; PETGGYASLP ; TKGQGGPPGA ; 350: GLAFPPPAAG ; LYVPHPHHKQ ; AGPAAHQLHV ; LGSRSQVFAS ; DSPPQSLLTP ; 400: SRNSLNVDLY ; ELGSTSVQQW ; PAATLARRDS ; LQKPGLEAPP ; RAHVAFRPDC ; 450: PVPSRTNSFN ; SHQPRPGPPG ; KAEPSLPAPN ; TVTAVTAAHI ; LHPVKSVRVL ; 500: RPEPQTAVGP ; SHPAWVPAPA ; PAPAPAPAPA ; AEGLDAKEEH ; ALALGGAGAF ; 550: PLDVEYGGPD ; RRCPPPPYPK ; HLLLRSKSEQ ; YDLDSLCAGM ; EQSLRAGPNE ; 600: PEGGDKSRKS ; AKGDKGGKDK ; KQIQTSPVPV ; RKNSRDEEKR ; ESRIKSYSPY ; 650: AFKFFMEQHV ; ENVIKTYQQK ; VNRRLQLEQE ; MAKAGLCEAE ; QEQMRKILYQ ; 700: KESNYNRLKR ; AKMDKSMFVK ; IKTLGIGAFG ; EVCLACKVDT ; HALYAMKTLR ; 750: KKDVLNRNQV ; AHVKAERDIL ; AEADNEWVVK ; LYYSFQDKDS ; LYFVMDYIPG ; 800: GDMMSLLIRM ; EVFPEHLARF ; YIAELTLAIE ; SVHKMGFIHR ; DIKPDNILID ; 850: LDGHIKLTDF ; GLCTGFRWTH ; NSKYYQKGSH ; VRQDSMEPSD ; LWDDVSNCRC ; 900: GDRLKTLEQR ; ARKQHQRCLA ; HSLVGTPNYI ; APEVLLRKGY ; TQLCDWWSVG ; 950: VILFEMLVGQ ; PPFLAPTPTE ; TQLKVINWEN ; TLHIPAQVKL ; SPEARDLITK ; 1000: LCCSADHRLG ; RNGADDLKAH ; PFFSAIDFSS ; DIRKQPAPYV ; PTISHPMDTS ; 1050: NFDPVDEESP ; WNDASEGSTK ; AWDTLTSPNN ; KHPEHAFYEF ; TFRRFFDDNG ; 1088: YPFRCPKPSG ; AEASQAESSD ; LESSDLVDQT ; EGCQPVYV
Sequence Length	1088
String	Q9NRM7
Sub Unit	Interacts with and is phosphorylated by AURKA. Binds to AR. Interacts with JUB during mitosis and this complex regulates organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts (via PPxY motif) with YAP1 (via WW domains). Interacts with MOBKL1A and MOBKL1B.

Uniprot	Q9NRM7
Gene Name	LATS2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:26524
Unigene	Hs.78960

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806408	E14088h	96T	$736		Add to Cart

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