JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase LATS1

SKU : BHE13807116

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E14087h
Alternative Names	Large tumor suppressor homolog 1 ; WARTS protein kinase ; h-warts ; WARTS
Categories	Elisa
Function	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase LATS1
Subcellular Location	Cytoplasm cytoskeleton centrosome Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.
Detection Range	0.156-10ng/mL
Entryname	LATS1_HUMAN
Method Type	Sandwich
Platform	PF00069
Protein Name	Serine/threonine-protein kinase LATS1
Sensitivity	0.078ng/mL
Sequence	50: MKRSEKPEGY ; RQMRPKTFPA ; SNYTVSSRQM ; LQEIRESLRN ; LSKPSDAAKA ; 100: EHNMSKMSTE ; DPRQVRNPPK ; FGTHHKALQE ; IRNSLLPFAN ; ETNSSRSTSE ; 150: VNPQMLQDLQ ; AAGFDEDMVI ; QALQKTNNRS ; IEAAIEFISK ; MSYQDPRREQ ; 200: MAAAAARPIN ; ASMKPGNVQQ ; SVNRKQSWKG ; SKESLVPQRH ; GPPLGESVAY ; 250: HSESPNSQTD ; VGRPLSGSGI ; SAFVQAHPSN ; GQRVNPPPPP ; QVRSVTPPPP ; 300: PRGQTPPPRG ; TTPPPPSWEP ; NSQTKRYSGN ; MEYVISRISP ; VPPGAWQEGY ; 350: PPPPLNTSPM ; NPPNQGQRGI ; SSVPVGRQPI ; IMQSSSKFNF ; PSGRPGMQNG ; 400: TGQTDFMIHQ ; NVVPAGTVNR ; QPPPPYPLTA ; ANGQSPSALQ ; TGGSAAPSSY ; 450: TNGSIPQSMM ; VPNRNSHNME ; LYNISVPGLQ ; TNWPQSSSAP ; AQSSPSSGHE ; 500: IPTWQPNIPV ; RSNSFNNPLG ; NRASHSANSQ ; PSATTVTAIT ; PAPIQQPVKS ; 550: MRVLKPELQT ; ALAPTHPSWI ; PQPIQTVQPS ; PFPEGTASNV ; TVMPPVAEAP ; 600: NYQGPPPPYP ; KHLLHQNPSV ; PPYESISKPS ; KEDQPSLPKE ; DESEKSYENV ; 650: DSGDKEKKQI ; TTSPITVRKN ; KKDEERRESR ; IQSYSPQAFK ; FFMEQHVENV ; 700: LKSHQQRLHR ; KKQLENEMMR ; VGLSQDAQDQ ; MRKMLCQKES ; NYIRLKRAKM ; 750: DKSMFVKIKT ; LGIGAFGEVC ; LARKVDTKAL ; YATKTLRKKD ; VLLRNQVAHV ; 800: KAERDILAEA ; DNEWVVRLYY ; SFQDKDNLYF ; VMDYIPGGDM ; MSLLIRMGIF ; 850: PESLARFYIA ; ELTCAVESVH ; KMGFIHRDIK ; PDNILIDRDG ; HIKLTDFGLC ; 900: TGFRWTHDSK ; YYQSGDHPRQ ; DSMDFSNEWG ; DPSSCRCGDR ; LKPLERRAAR ; 950: QHQRCLAHSL ; VGTPNYIAPE ; VLLRTGYTQL ; CDWWSVGVIL ; FEMLVGQPPF ; 1000: LAQTPLETQM ; KVINWQTSLH ; IPPQAKLSPE ; ASDLIIKLCR ; GPEDRLGKNG ; 1050: ADEIKAHPFF ; KTIDFSSDLR ; QQSASYIPKI ; THPTDTSNFD ; PVDPDKLWSD ; 1100: DNEEENVNDT ; LNGWYKNGKH ; PEHAFYEFTF ; RRFFDDNGYP ; YNYPKPIEYE ; 1130: YINSQGSEQQ ; SDEDDQNTGS ; EIKNRDLVYV ;
Sequence Length	1130
String	O95835
Sub Unit	Complexes with CDK1 in early mitosis. LATS1-associated CDK1 has no mitotic cyclin partner and no apparent kinase activity. Binds phosphorylated ZYX, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. Interacts (via PPxY motif 2) with YAP1 (via WW domains). Interacts with MOBKL1A and MOBKL1B.

Uniprot	O95835
Gene Name	LATS1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9113
Unigene	Hs.716697

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13807116	E14087h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.