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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/threonine-protein kinase 4

SKU : BHE13810412

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E13100h
Alternative Names	Mammalian STE20-like protein kinase 1 ; MST-1 ; STE20-like kinase MST1 ; Serine/threonine-protein kinase Krs-2 ; KRS2 ; MST1
Categories	Elisa
Function	Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
Specificity	Natural and recombinant Human Serine/threonine-protein kinase 4
Subcellular Location	Cytoplasm Nucleus The caspase-cleaved form cycles between the nucleus and cytoplasm.
Detection Range	0.156-10ng/mL
Entryname	STK4_HUMAN
Method Type	Sandwich
Platform	PF11629
Protein Name	Serine/threonine-protein kinase 4
Sensitivity	0.078ng/mL
Sequence	50: METVQLRNPP ; RRQLKKLDED ; SLTKQPEEVF ; DVLEKLGEGS ; YGSVYKAIHK ; 100: ETGQIVAIKQ ; VPVESDLQEI ; IKEISIMQQC ; DSPHVVKYYG ; SYFKNTDLWI ; 150: VMEYCGAGSV ; SDIIRLRNKT ; LTEDEIATIL ; QSTLKGLEYL ; HFMRKIHRDI ; 200: KAGNILLNTE ; GHAKLADFGV ; AGQLTDTMAK ; RNTVIGTPFW ; MAPEVIQEIG ; 250: YNCVADIWSL ; GITAIEMAEG ; KPPYADIHPM ; RAIFMIPTNP ; PPTFRKPELW ; 300: SDNFTDFVKQ ; CLVKSPEQRA ; TATQLLQHPF ; VRSAKGVSIL ; RDLINEAMDV ; 350: KLKRQESQQR ; EVDQDDEENS ; EEDEMDSGTM ; VRAVGDEMGT ; VRVASTMTDG ; 400: ANTMIEHDDT ; LPSQLGTMVI ; NAEDEEEEGT ; MKRRDETMQP ; AKPSFLEYFE ; 450: QKEKENQINS ; FGKSVPGPLK ; NSSDWKIPQD ; GDYEFLKSWT ; VEDLQKRLLA ; 487: LDPMMEQEIE ; EIRQKYQSKR ; QPILDAIEAK ; KRRQQNF
Sequence Length	487
String	Q13043
Sub Unit	Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1, which leads to enzyme activation. Interacts with FOXO3.

Uniprot	Q13043
Gene Name	STK4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6789
Unigene	Hs.472838

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810412	E13100h	96T	$736		Add to Cart

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