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ELISA Kit for Human Serine-protein kinase ATM

SKU : BHE13801476

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1361h
Alternative Names	Ataxia telangiectasia mutated ; A-T mutated
Categories	Elisa
Function	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.
Specificity	Natural and recombinant Human Serine-protein kinase ATM
Subcellular Location	Nucleus Cytoplasmic vesicle Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Detection Range	6.25-400nmol/L
Entryname	ATM_HUMAN
Method Type	Sandwich
Platform	PF02259
Protein Name	Serine-protein kinase ATM
Sensitivity	2.9nmol/L
Sequence	50: MSLVLNDLLI ; CCRQLEHDRA ; TERKKEVEKF ; KRLIRDPETI ; KHLDRHSDSK ; 100: QGKYLNWDAV ; FRFLQKYIQK ; ETECLRIAKP ; NVSASTQASR ; QKKMQEISSL ; 150: VKYFIKCANR ; RAPRLKCQEL ; LNYIMDTVKD ; SSNGAIYGAD ; CSNILLKDIL ; 200: SVRKYWCEIS ; QQQWLELFSV ; YFRLYLKPSQ ; DVHRVLVARI ; IHAVTKGCCS ; 250: QTDGLNSKFL ; DFFSKAIQCA ; RQEKSSSGLN ; HILAALTIFL ; KTLAVNFRIR ; 300: VCELGDEILP ; TLLYIWTQHR ; LNDSLKEVII ; ELFQLQIYIH ; HPKGAKTQEK ; 350: GAYESTKWRS ; ILYNLYDLLV ; NEISHIGSRG ; KYSSGFRNIA ; VKENLIELMA ; 400: DICHQVFNED ; TRSLEISQSY ; TTTQRESSDY ; SVPCKRKKIE ; LGWEVIKDHL ; 450: QKSQNDFDLV ; PWLQIATQLI ; SKYPASLPNC ; ELSPLLMILS ; QLLPQQRHGE ; 500: RTPYVLRCLT ; EVALCQDKRS ; NLESSQKSDL ; LKLWNKIWCI ; TFRGISSEQI ; 550: QAENFGLLGA ; IIQGSLVEVD ; REFWKLFTGS ; ACRPSCPAVC ; CLTLALTTSI ; 600: VPGTVKMGIE ; QNMCEVNRSF ; SLKESIMKWL ; LFYQLEGDLE ; NSTEVPPILH ; 650: SNFPHLVLEK ; ILVSLTMKNC ; KAAMNFFQSV ; PECEHHQKDK ; EELSFSEVEE ; 700: LFLQTTFDKM ; DFLTIVRECG ; IEKHQSSIGF ; SVHQNLKESL ; DRCLLGLSEQ ; 750: LLNNYSSEIT ; NSETLVRCSR ; LLVGVLGCYC ; YMGVIAEEEA ; YKSELFQKAK ; 800: SLMQCAGESI ; TLFKNKTNEE ; FRIGSLRNMM ; QLCTRCLSNC ; TKKSPNKIAS ; 850: GFFLRLLTSK ; LMNDIADICK ; SLASFIKKPF ; DRGEVESMED ; DTNGNLMEVE ; 900: DQSSMNLFND ; YPDSSVSDAN ; EPGESQSTIG ; AINPLAEEYL ; SKQDLLFLDM ; 950: LKFLCLCVTT ; AQTNTVSFRA ; ADIRRKLLML ; IDSSTLEPTK ; SLHLHMYLML ; 1000: LKELPGEEYP ; LPMEDVLELL ; KPLSNVCSLY ; RRDQDVCKTI ; LNHVLHVVKN ; 1050: LGQSNMDSEN ; TRDAQGQFLT ; VIGAFWHLTK ; ERKYIFSVRM ; ALVNCLKTLL ; 1100: EADPYSKWAI ; LNVMGKDFPV ; NEVFTQFLAD ; NHHQVRMLAA ; ESINRLFQDT ; 1150: KGDSSRLLKA ; LPLKLQQTAF ; ENAYLKAQEG ; MREMSHSAEN ; PETLDEIYNR ; 1200: KSVLLTLIAV ; VLSCSPICEK ; QALFALCKSV ; KENGLEPHLV ; KKVLEKVSET ; 1250: FGYRRLEDFM ; ASHLDYLVLE ; WLNLQDTEYN ; LSSFPFILLN ; YTNIEDFYRS ; 1300: CYKVLIPHLV ; IRSHFDEVKS ; IANQIQEDWK ; SLLTDCFPKI ; LVNILPYFAY ; 1350: EGTRDSGMAQ ; QRETATKVYD ; MLKSENLLGK ; QIDHLFISNL ; PEIVVELLMT ; 1400: LHEPANSSAS ; QSTDLCDFSG ; DLDPAPNPPH ; FPSHVIKATF ; AYISNCHKTK ; 1450: LKSILEILSK ; SPDSYQKILL ; AICEQAAETN ; NVYKKHRILK ; IYHLFVSLLL ; 1500: KDIKSGLGGA ; WAFVLRDVIY ; TLIHYINQRP ; SCIMDVSLRS ; FSLCCDLLSQ ; 1550: VCQTAVTYCK ; DALENHLHVI ; VGTLIPLVYE ; QVEVQKQVLD ; LLKYLVIDNK ; 1600: DNENLYITIK ; LLDPFPDHVV ; FKDLRITQQK ; IKYSRGPFSL ; LEEINHFLSV ; 1650: SVYDALPLTR ; LEGLKDLRRQ ; LELHKDQMVD ; IMRASQDNPQ ; DGIMVKLVVN ; 1700: LLQLSKMAIN ; HTGEKEVLEA ; VGSCLGEVGP ; IDFSTIAIQH ; SKDASYTKAL ; 1750: KLFEDKELQW ; TFIMLTYLNN ; TLVEDCVKVR ; SAAVTCLKNI ; LATKTGHSFW ; 1800: EIYKMTTDPM ; LAYLQPFRTS ; RKKFLEVPRF ; DKENPFEGLD ; DINLWIPLSE ; 1850: NHDIWIKTLT ; CAFLDSGGTK ; CEILQLLKPM ; CEVKTDFCQT ; VLPYLIHDIL ; 1900: LQDTNESWRN ; LLSTHVQGFF ; TSCLRHFSQT ; SRSTTPANLD ; SESEHFFRCC ; 1950: LDKKSQRTML ; AVVDYMRRQK ; RPSSGTIFND ; AFWLDLNYLE ; VAKVAQSCAA ; 2000: HFTALLYAEI ; YADKKSMDDQ ; EKRSLAFEEG ; SQNTTISSLS ; EKSKEETGIS ; 2050: LQDLLLEIYR ; SIGEPDSLYG ; CGGGKMLQPI ; TRLRTYEHEA ; MWGKALVTYD ; 2100: LETAIPSSTR ; QAGIIQALQN ; LGLCHILSVY ; LKGLDYENKD ; WCPELEELHY ; 2150: QAAWRNMQWD ; HCTSVSKEVE ; GTSYHESLYN ; ALQSLRDREF ; STFYESLKYA ; 2200: RVKEVEEMCK ; RSLESVYSLY ; PTLSRLQAIG ; ELESIGELFS ; RSVTHRQLSE ; 2250: VYIKWQKHSQ ; LLKDSDFSFQ ; EPIMALRTVI ; LEILMEKEMD ; NSQRECIKDI ; 2300: LTKHLVELSI ; LARTFKNTQL ; PERAIFQIKQ ; YNSVSCGVSE ; WQLEEAQVFW ; 2350: AKKEQSLALS ; ILKQMIKKLD ; ASCAANNPSL ; KLTYTECLRV ; CGNWLAETCL ; 2400: ENPAVIMQTY ; LEKAVEVAGN ; YDGESSDELR ; NGKMKAFLSL ; ARFSDTQYQR ; 2450: IENYMKSSEF ; ENKQALLKRA ; KEEVGLLREH ; KIQTNRYTVK ; VQRELELDEL ; 2500: ALRALKEDRK ; RFLCKAVENY ; INCLLSGEEH ; DMWVFRLCSL ; WLENSGVSEV ; 2550: NGMMKRDGMK ; IPTYKFLPLM ; YQLAARMGTK ; MMGGLGFHEV ; LNNLISRISM ; 2600: DHPHHTLFII ; LALANANRDE ; FLTKPEVARR ; SRITKNVPKQ ; SSQLDEDRTE ; 2650: AANRIICTIR ; SRRPQMVRSV ; EALCDAYIIL ; ANLDATQWKT ; QRKGINIPAD ; 2700: QPITKLKNLE ; DVVVPTMEIK ; VDHTGEYGNL ; VTIQSFKAEF ; RLAGGVNLPK ; 2750: IIDCVGSDGK ; ERRQLVKGRD ; DLRQDAVMQQ ; VFQMCNTLLQ ; RNTETRKRKL ; 2800: TICTYKVVPL ; SQRSGVLEWC ; TGTVPIGEFL ; VNNEDGAHKR ; YRPNDFSAFQ ; 2850: CQKKMMEVQK ; KSFEEKYEVF ; MDVCQNFQPV ; FRYFCMEKFL ; DPAIWFEKRL ; 2900: AYTRSVATSS ; IVGYILGLGD ; RHVQNILINE ; QSAELVHIDL ; GVAFEQGKIL ; 2950: PTPETVPFRL ; TRDIVDGMGI ; TGVEGVFRRC ; CEKTMEVMRN ; SQETLLTIVE ; 3000: VLLYDPLFDW ; TMNPLKALYL ; QQRPEDETEL ; HPTLNADDQE ; CKRNLSDIDQ ; 3050: SFNKVAERVL ; MRLQEKLKGV ; EEGTVLSVGG ; QVNLLIQQAI ; DPKNLSRLFP ; 3056: GWKAWV
Sequence Length	3056
String	Q13315
Sub Unit	Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, upregulates TP53. Interacts with DCLRE1C, KAT8, KAT5, OBFC2B, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1.

Uniprot	Q13315
Gene Name	ATM
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:472
Unigene	Hs.367437

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