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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine protease HTRA2, mitochondrial

SKU : BHE13805905

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15152h
Alternative Names	High temperature requirement protein A2 ; HtrA2 ; Omi stress-regulated endoprotease ; Serine protease 25 ; Serine proteinase OMI ; OMI ; PRSS25
Categories	Elisa
Function	Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Specificity	Natural and recombinant Human Serine protease HTRA2, mitochondrial
Subcellular Location	Mitochondrion intermembrane space Mitochondrion membrane Single-pass membrane protein Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Detection Range	0.156-10ng/ml
Entryname	HTRA2_HUMAN
Method Type	Sandwich
Platform	PF13180
Protein Name	Serine protease HTRA2, mitochondrial
Sensitivity	0.079ng/mL
Sequence	50: MAAPRAGRGA ; GWSLRAWRAL ; GGIRWGRRPR ; LTPDLRALLT ; SGTSDPRARV ; 100: TYGTPSLWAR ; LSVGVTEPRA ; CLTSGTPGPR ; AQLTAVTPDT ; RTREASENSG ; 150: TRSRAWLAVA ; LGAGGAVLLL ; LWGGGRGPPA ; VLAAVPSPPP ; ASPRSQYNFI ; 200: ADVVEKTAPA ; VVYIEILDRH ; PFLGREVPIS ; NGSGFVVAAD ; GLIVTNAHVV ; 250: ADRRRVRVRL ; LSGDTYEAVV ; TAVDPVADIA ; TLRIQTKEPL ; PTLPLGRSAD ; 300: VRQGEFVVAM ; GSPFALQNTI ; TSGIVSSAQR ; PARDLGLPQT ; NVEYIQTDAA ; 350: IDFGNSGGPL ; VNLDGEVIGV ; NTMKVTAGIS ; FAIPSDRLRE ; FLHRGEKKNS ; 400: SSGISGSQRR ; YIGVMMLTLS ; PSILAELQLR ; EPSFPDVQHG ; VLIHKVILGS ; 450: PAHRAGLRPG ; DVILAIGEQM ; VQNAEDVYEA ; VRTQSQLAVQ ; IRRGRETLTL ; 458: YVTPEVTE
Sequence Length	458
String	O43464
Sub Unit	Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.

Uniprot	O43464
Gene Name	HTRA2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:27429
Unigene	Hs.469045

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805905	E15152h	96T	$736		Add to Cart

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