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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Serine/arginine-rich splicing factor 1

SKU : BHE13809387

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8282h
Alternative Names	Alternative-splicing factor 1 ; ASF-1 ; Splicing factor ; arginine/serine-rich 1 ; pre-mRNA-splicing factor SF2 ; P33 subunit ; ASF ; SF2 ; SF2P33 ; SFRS1 ; OK/SW-cl.3
Categories	Elisa
Function	Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors.
Specificity	Natural and recombinant Human Serine/arginine-rich splicing factor 1
Subcellular Location	Cytoplasm Nucleus speckle In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Detection Range	0.312-20ng/mL
Entryname	SRSF1_HUMAN
Method Type	Sandwich
Platform	PF00076
Protein Name	Serine/arginine-rich splicing factor 1
Sensitivity	0.12ng/mL
Sequence	50: MSGGGVIRGP ; AGNNDCRIYV ; GNLPPDIRTK ; DIEDVFYKYG ; AIRDIDLKNR ; 100: RGGPPFAFVE ; FEDPRDAEDA ; VYGRDGYDYD ; GYRLRVEFPR ; SGRGTGRGGG ; 150: GGGGGGAPRG ; RYGPPSRRSE ; NRVVVSGLPP ; SGSWQDLKDH ; MREAGDVCYA ; 200: DVYRDGTGVV ; EFVRKEDMTY ; AVRKLDNTKF ; RSHEGETAYI ; RVKVDGPRSP ; 248: SYGRSRSRSR ; SRSRSRSRSN ; SRSRSYSPRR ; SRGSPRYSPR ; HSRSRSRT
Sequence Length	248
String	Q07955
Sub Unit	Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).

Uniprot	Q07955
Gene Name	SRSF1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6426
Unigene	Hs.68714

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809387	E8282h	96T	$736		Add to Cart

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