CDw108 ; JMH blood group antigen ; John-Milton-Hargen human blood group Ag ; Semaphorin-K1 ; Sema K1 ; Semaphorin-L ; Sema L ; CD108 ; CD108 ; SEMAL
Categories
Elisa
Function
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Specificity
Natural and recombinant Human Semaphorin-7A
Subcellular Location
Cell membrane Lipid-anchor GPI-anchor Extracellular side Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.