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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Secretory phospholipase A2 receptor

SKU : BHE13808840

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2020h
Alternative Names	180 kDa secretory phospholipase A2 receptor ; C-type lectin domain family 13 member C ; M-type receptor ; CLEC13C
Categories	Elisa
Function	Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.
Specificity	Natural and recombinant Human Secretory phospholipase A2 receptor
Subcellular Location	Isoform 2 Secreted
Detection Range	0.625-40ng/mL
Entryname	PLA2R_HUMAN
Method Type	Sandwich
Platform	PF00040
Protein Name	Secretory phospholipase A2 receptor
Sensitivity	0.156ng/mL
Sequence	50: MLLSPSLLLL ; LLLGAPRGCA ; EGVAAALTPE ; RLLEWQDKGI ; FVIQSESLKK ; 100: CIQAGKSVLT ; LENCKQANKH ; MLWKWVSNHG ; LFNIGGSGCL ; GLNFSAPEQP ; 150: LSLYECDSTL ; VSLRWRCNRK ; MITGPLQYSV ; QVAHDNTVVA ; SRKYIHKWIS ; 200: YGSGGGDICE ; YLHKDLHTIK ; GNTHGMPCMF ; PFQYNHQWHH ; ECTREGREDD ; 250: LLWCATTSRY ; ERDEKWGFCP ; DPTSAEVGCD ; TIWEKDLNSH ; ICYQFNLLSS ; 300: LSWSEAHSSC ; QMQGGTLLSI ; TDETEENFIR ; EHMSSKTVEV ; WMGLNQLDEH ; 350: AGWQWSDGTP ; LNYLNWSPEV ; NFEPFVEDHC ; GTFSSFMPSA ; WRSRDCESTL ; 400: PYICKKYLNH ; IDHEIVEKDA ; WKYYATHCEP ; GWNPYNRNCY ; KLQKEEKTWH ; 450: EALRSCQADN ; SALIDITSLA ; EVEFLVTLLG ; DENASETWIG ; LSSNKIPVSF ; 500: EWSNDSSVIF ; TNWHTLEPHI ; FPNRSQLCVS ; AEQSEGHWKV ; KNCEERLFYI ; 550: CKKAGHVLSD ; AESGCQEGWE ; RHGGFCYKID ; TVLRSFDQAS ; SGYYCPPALV ; 600: TITNRFEQAF ; ITSLISSVVK ; MKDSYFWIAL ; QDQNDTGEYT ; WKPVGQKPEP ; 650: VQYTHWNTHQ ; PRYSGGCVAM ; RGRHPLGRWE ; VKHCRHFKAM ; SLCKQPVENQ ; 700: EKAEYEERWP ; FHPCYLDWES ; EPGLASCFKV ; FHSEKVLMKR ; TWREAEAFCE ; 750: EFGAHLASFA ; HIEEENFVNE ; LLHSKFNWTE ; ERQFWIGFNK ; RNPLNAGSWE ; 800: WSDRTPVVSS ; FLDNTYFGED ; ARNCAVYKAN ; KTLLPLHCGS ; KREWICKIPR ; 850: DVKPKIPFWY ; QYDVPWLFYQ ; DAEYLFHTFA ; SEWLNFEFVC ; SWLHSDLLTI ; 900: HSAHEQEFIH ; SKIKALSKYG ; ASWWIGLQEE ; RANDEFRWRD ; GTPVIYQNWD ; 950: TGRERTVNNQ ; SQRCGFISSI ; TGLWGSEECS ; VSMPSICKRK ; KVWLIEKKKD ; 1000: TPKQHGTCPK ; GWLYFNYKCL ; LLNIPKDPSS ; WKNWTHAQHF ; CAEEGGTLVA ; 1050: IESEVEQAFI ; TMNLFGQTTS ; VWIGLQNDDY ; ETWLNGKPVV ; YSNWSPFDII ; 1100: NIPSHNTTEV ; QKHIPLCALL ; SSNPNFHFTG ; KWYFEDCGKE ; GYGFVCEKMQ ; 1150: DTSGHGVNTS ; DMYPMPNTLE ; YGNRTYKIIN ; ANMTWYAAIK ; TCLMHKAQLV ; 1200: SITDQYHQSF ; LTVVLNRLGY ; AHWIGLFTTD ; NGLNFDWSDG ; TKSSFTFWKD ; 1250: EESSLLGDCV ; FADSNGRWHS ; TACESFLQGA ; ICHVPPETRQ ; SEHPELCSET ; 1300: SIPWIKFKSN ; CYSFSTVLDS ; MSFEAAHEFC ; KKEGSNLLTI ; KDEAENAFLL ; 1350: EELFAFGSSV ; QMVWLNAQFD ; GNNETIKWFD ; GTPTDQSNWG ; IRKPDTDYFK ; 1400: PHHCVALRIP ; EGLWQLSPCQ ; EKKGFICKME ; ADIHTAEALP ; EKGPSHSIIP ; 1450: LAVVLTLIVI ; VAICTLSFCI ; YKHNGGFFRR ; LAGFRNPYYP ; ATNFSTVYLE ; 1463: ENILISDLEK ; SDQ
Sequence Length	1463
String	Q13018

Uniprot	Q13018
Gene Name	PLA2R1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:22925
Unigene	Hs.410477

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808840	E2020h	96T	$736		Add to Cart

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