CD36 and LIMPII analogous 1 ; CLA-1 ; CD36 antigen-like 1 ; Collagen type I receptor ; thrombospondin receptor-like 1 ; SR-BI ; CD36 ; CD36L1 ; CLA1
Categories
Elisa
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
Specificity
Natural and recombinant Human Scavenger receptor class B member 1
Subcellular Location
Cell membrane Multi-pass membrane protein Membrane caveola Multi-pass membrane protein Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1.