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ELISA Kit for Human S-phase kinase-associated protein 2

SKU : BHE13810471

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9870h
Alternative Names	Cyclin-A/CDK2-associated protein p45 ; F-box protein Skp2 ; F-box/LRR-repeat protein 1 ; p45skp2 ; FBXL1
Categories	Elisa
Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.
Specificity	Natural and recombinant Human S-phase kinase-associated protein 2
Detection Range	0.156-10ng/mL
Entryname	SKP2_HUMAN
Method Type	Sandwich
Protein Name	S-phase kinase-associated protein 2
Sensitivity	0.089ng/mL
Sequence	50: MHRKHLQEIP ; DLSSNVATSF ; TWGWDSSKTS ; ELLSGMGVSA ; LEKEEPDSEN ; 100: IPQELLSNLG ; HPESPPRKRL ; KSKGSDKDFV ; IVRRPKLNRE ; NFPGVSWDSL ; 150: PDELLLGIFS ; CLCLPELLKV ; SGVCKRWYRL ; ASDESLWQTL ; DLTGKNLHPD ; 200: VTGRLLSQGV ; IAFRCPRSFM ; DQPLAEHFSP ; FRVQHMDLSN ; SVIEVSTLHG ; 250: ILSQCSKLQN ; LSLEGLRLSD ; PIVNTLAKNS ; NLVRLNLSGC ; SGFSEFALQT ; 300: LLSSCSRLDE ; LNLSWCFDFT ; EKHVQVAVAH ; VSETITQLNL ; SGYRKNLQKS ; 350: DLSTLVRRCP ; NLVHLDLSDS ; VMLKNDCFQE ; FFQLNYLQHL ; SLSRCYDIIP ; 400: ETLLELGEIP ; TLKTLQVFGI ; VPDGTLQLLK ; EALPHLQINC ; SHFTTIARPT ; 424: IGNKKNQEIW ; GIKCRLTLQK ; PSCL
Sequence Length	424
String	Q13309
Sub Unit	Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 and MLL. Interacts with TRIM21.

Uniprot	Q13309
Gene Name	SKP2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6502
Unigene	Hs.23348

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810471	E9870h	96T	$736		Add to Cart

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