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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Runt-related transcription factor 1

SKU : BHE13810198

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10487h
Alternative Names	Acute myeloid leukemia 1 protein ; Core-binding factor subunit alpha-2 ; CBF-alpha-2 ; Oncogene AML-1 ; Polyomavirus enhancer-binding protein 2 alpha B subunit ; PEA2-alpha B ; SL3-3 enhancer factor 1 alpha B subunit ; SL3/AKV core-binding factor alpha B subunit ; AML1 ; CBFA2
Categories	Elisa
Function	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.
Specificity	Natural and recombinant Human Runt-related transcription factor 1
Subcellular Location	Nucleus
Detection Range	31.2-2000pg/mL
Entryname	RUNX1_HUMAN
Method Type	Sandwich
Platform	PF00853
Protein Name	Runt-related transcription factor 1
Sensitivity	10pg/mL
Sequence	50: MRIPVDASTS ; RRFTPPSTAL ; SPGKMSEALP ; LGAPDAGAAL ; AGKLRSGDRS ; 100: MVEVLADHPG ; ELVRTDSPNF ; LCSVLPTHWR ; CNKTLPIAFK ; VVALGDVPDG ; 150: TLVTVMAGND ; ENYSAELRNA ; TAAMKNQVAR ; FNDLRFVGRS ; GRGKSFTLTI ; 200: TVFTNPPQVA ; TYHRAIKITV ; DGPREPRRHR ; QKLDDQTKPG ; SLSFSERLSE ; 250: LEQLRRTAMR ; VSPHHPAPTP ; NPRASLNHST ; AFNPQPQSQM ; QDTRQIQPSP ; 300: PWSYDQSYQY ; LGSIASPSVH ; PATPISPGRA ; SGMTTLSAEL ; SSRLSTAPDL ; 350: TAFSDPRQFP ; ALPSISDPRM ; HYPGAFTYSP ; TPVTSGIGIG ; MSAMGSATRY ; 400: HTYLPPPYPG ; SSQAQGGPFQ ; ASSPSYHLYY ; GASAGSYQFS ; MVGGERSPPR ; 450: ILPPCTNAST ; GSALLNPSLP ; NQSDVVEAEG ; SHSNSPTNMA ; PSARLEEAVW ; 453: RPY
Sequence Length	453
String	Q01196
Sub Unit	Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogation of transactivating and DNA-binding properties of RUNX1. Interacts with YAP1. Interacts with HIPK2 (By similarity). Interaction with CDK6 prevents myeloid differentiation, reducing its transcription transactivation activity.

Uniprot	Q01196
Gene Name	RUNX1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:861
Unigene	Hs.149261

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810198	E10487h	96T	$736		Add to Cart

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