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Home / Assay Kits / ELISA Kits

ELISA Kit for Human RISC-loading complex subunit TARBP2

SKU : BHE13811778

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3425h
Alternative Names	TAR RNA-binding protein 2 ; Trans-activation-responsive RNA-binding protein ; TRBP
Categories	Elisa
Function	Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.
Specificity	Natural and recombinant Human RISC-loading complex subunit TARBP2
Subcellular Location	Cytoplasm Cytoplasm perinuclear region Nucleus
Detection Range	0.312-20ng/ml
Entryname	TRBP2_HUMAN
Method Type	Sandwich
Platform	PF00035
Protein Name	RISC-loading complex subunit TARBP2
Sensitivity	0.19ng/mL
Sequence	50: MSEEEQGSGT ; TTGCGLPSIE ; QMLAANPGKT ; PISLLQEYGT ; RIGKTPVYDL ; 100: LKAEGQAHQP ; NFTFRVTVGD ; TSCTGQGPSK ; KAAKHKAAEV ; ALKHLKGGSM ; 150: LEPALEDSSS ; FSPLDSSLPE ; DIPVFTAAAA ; ATPVPSVVLT ; RSPPMELQPP ; 200: VSPQQSECNP ; VGALQELVVQ ; KGWRLPEYTV ; TQESGPAHRK ; EFTMTCRVER ; 250: FIEIGSGTSK ; KLAKRNAAAK ; MLLRVHTVPL ; DARDGNEVEP ; DDDHFSIGVG ; 300: SRLDGLRNRG ; PGCTWDSLRN ; SVGEKILSLR ; SCSLGSLGAL ; GPACCRVLSE ; 350: LSEEQAFHVS ; YLDIEELSLS ; GLCQCLVELS ; TQPATVCHGS ; ATTREAARGE ; 366: AARRALQYLK ; IMAGSK
Sequence Length	366
String	Q15633
Sub Unit	Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9, EIF6, MOV10 and PRKRA. Associates with the 60S ribosome.

Uniprot	Q15633
Gene Name	TARBP2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6895
Unigene	Hs.326

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811778	E3425h	96T	$736		Add to Cart

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