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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Ribosomal protein S6 kinase beta-1

SKU : BHE13806841

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3119h
Alternative Names	70 kDa ribosomal protein S6 kinase 1 ; P70S6K1 ; Ribosomal protein S6 kinase I ; Serine/threonine-protein kinase 14A ; p70 ribosomal S6 kinase alpha ; p70 S6 kinase alpha ; STK14A
Categories	Elisa
Function	Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-99' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-99'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates GSK3B at 'Ser-9' under conditions leading to loss of the TSC1-TSC2 complex. Phosphorylates POLDIP3.
Specificity	Natural and recombinant Human Ribosomal protein S6 kinase beta-1
Subcellular Location	Isoform Alpha II Cytoplasm
Entryname	KS6B1_HUMAN
Platform	PF00069
Protein Name	Ribosomal protein S6 kinase beta-1
Sequence	50: MRRRRRRDGF ; YPAPDFRDRE ; AEDMAGVFDI ; DLDQPEDAGS ; EDELEEGGQL ; 100: NESMDHGGVG ; PYELGMEHCE ; KFEISETSVN ; RGPEKIRPEC ; FELLRVLGKG ; 150: GYGKVFQVRK ; VTGANTGKIF ; AMKVLKKAMI ; VRNAKDTAHT ; KAERNILEEV ; 200: KHPFIVDLIY ; AFQTGGKLYL ; ILEYLSGGEL ; FMQLEREGIF ; MEDTACFYLA ; 250: EISMALGHLH ; QKGIIYRDLK ; PENIMLNHQG ; HVKLTDFGLC ; KESIHDGTVT ; 300: HTFCGTIEYM ; APEILMRSGH ; NRAVDWWSLG ; ALMYDMLTGA ; PPFTGENRKK ; 350: TIDKILKCKL ; NLPPYLTQEA ; RDLLKKLLKR ; NAASRLGAGP ; GDAGEVQAHP ; 400: FFRHINWEEL ; LARKVEPPFK ; PLLQSEEDVS ; QFDSKFTRQT ; PVDSPDDSTL ; 450: SESANQVFLG ; FTYVAPSVLE ; SVKEKFSFEP ; KIRSPRRFIG ; SPRTPVSPVK ; 500: FSPGDFWGRG ; ASASTANPQT ; PVEYPMETSG ; IEQMDVTMSG ; EASAPLPIRQ ; 525: PNSGPYKKQA ; FPMISKRPEH ; LRMNL
Sequence Length	525
String	P23443
Sub Unit	Interacts with PPP1R9A/neurabin-1 (By similarity). Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4.

Uniprot	P23443
Gene Name	RPS6KB1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6198
Unigene	Hs.463642

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806841	E3119h	96T	$736		Add to Cart

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