JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Rho-associated protein kinase 1

SKU : BHE13809399

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E15189h
Alternative Names	Renal carcinoma antigen NY-REN-35 ; Rho-associated ; coiled-coil-containing protein kinase 1 ; Rho-associated ; coiled-coil-containing protein kinase I ; ROCK-I ; p160 ROCK-1 ; p160ROCK
Categories	Elisa
Function	Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.
Specificity	Natural and recombinant Human Rho-associated protein kinase 1
Subcellular Location	Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker (By similarity). A small proportion is associated with Golgi membranes.
Detection Range	0.625-40ng/mL
Entryname	ROCK1_HUMAN
Method Type	Sandwich
Platform	PF02185
Protein Name	Rho-associated protein kinase 1
Sensitivity	0.328ng/mL
Sequence	50: MSTGDSFETR ; FEKMDNLLRD ; PKSEVNSDCL ; LDGLDALVYD ; LDFPALRKNK ; 100: NIDNFLSRYK ; DTINKIRDLR ; MKAEDYEVVK ; VIGRGAFGEV ; QLVRHKSTRK ; 150: VYAMKLLSKF ; EMIKRSDSAF ; FWEERDIMAF ; ANSPWVVQLF ; YAFQDDRYLY ; 200: MVMEYMPGGD ; LVNLMSNYDV ; PEKWARFYTA ; EVVLALDAIH ; SMGFIHRDVK ; 250: PDNMLLDKSG ; HLKLADFGTC ; MKMNKEGMVR ; CDTAVGTPDY ; ISPEVLKSQG ; 300: GDGYYGRECD ; WWSVGVFLYE ; MLVGDTPFYA ; DSLVGTYSKI ; MNHKNSLTFP ; 350: DDNDISKEAK ; NLICAFLTDR ; EVRLGRNGVE ; EIKRHLFFKN ; DQWAWETLRD ; 400: TVAPVVPDLS ; SDIDTSNFDD ; LEEDKGEEET ; FPIPKAFVGN ; QLPFVGFTYY ; 450: SNRRYLSSAN ; PNDNRTSSNA ; DKSLQESLQK ; TIYKLEEQLH ; NEMQLKDEME ; 500: QKCRTSNIKL ; DKIMKELDEE ; GNQRRNLEST ; VSQIEKEKML ; LQHRINEYQR ; 550: KAEQENEKRR ; NVENEVSTLK ; DQLEDLKKVS ; QNSQLANEKL ; SQLQKQLEEA ; 600: NDLLRTESDT ; AVRLRKSHTE ; MSKSISQLES ; LNRELQERNR ; ILENSKSQTD ; 650: KDYYQLQAIL ; EAERRDRGHD ; SEMIGDLQAR ; ITSLQEEVKH ; LKHNLEKVEG ; 700: ERKEAQDMLN ; HSEKEKNNLE ; IDLNYKLKSL ; QQRLEQEVNE ; HKVTKARLTD ; 750: KHQSIEEAKS ; VAMCEMEKKL ; KEEREAREKA ; ENRVVQIEKQ ; CSMLDVDLKQ ; 800: SQQKLEHLTG ; NKERMEDEVK ; NLTLQLEQES ; NKRLLLQNEL ; KTQAFEADNL ; 850: KGLEKQMKQE ; INTLLEAKRL ; LEFELAQLTK ; QYRGNEGQMR ; ELQDQLEAEQ ; 900: YFSTLYKTQV ; KELKEEIEEK ; NRENLKKIQE ; LQNEKETLAT ; QLDLAETKAE ; 950: SEQLARGLLE ; EQYFELTQES ; KKAASRNRQE ; ITDKDHTVSR ; LEEANSMLTK ; 1000: DIEILRRENE ; ELTEKMKKAE ; EEYKLEKEEE ; ISNLKAAFEK ; NINTERTLKT ; 1050: QAVNKLAEIM ; NRKDFKIDRK ; KANTQDLRKK ; EKENRKLQLE ; LNQEREKFNQ ; 1100: MVVKHQKELN ; DMQAQLVEEC ; AHRNELQMQL ; ASKESDIEQL ; RAKLLDLSDS ; 1150: TSVASFPSAD ; ETDGNLPESR ; IEGWLSVPNR ; GNIKRYGWKK ; QYVVVSSKKI ; 1200: LFYNDEQDKE ; QSNPSMVLDI ; DKLFHVRPVT ; QGDVYRAETE ; EIPKIFQILY ; 1250: ANEGECRKDV ; EMEPVQQAEK ; TNFQNHKGHE ; FIPTLYHFPA ; NCDACAKPLW ; 1300: HVFKPPPALE ; CRRCHVKCHR ; DHLDKKEDLI ; CPCKVSYDVT ; SARDMLLLAC ; 1350: SQDEQKKWVT ; HLVKKIPKNP ; PSGFVRASPR ; TLSTRSTANQ ; SFRKVVKNTS ; 1354: GKTS
Sequence Length	1354
String	Q13464
Sub Unit	Homodimer. Interacts with RHOB, RHOC, MYLC2B snd PTEN (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner.

Uniprot	Q13464
Gene Name	ROCK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6093
Unigene	Hs.306307

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13809399	E15189h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.