Embryonal carcinoma differentiation-regulated protein ; Mammalian retrotransposon-derived protein 2 ; Myelin expression factor 3-like protein 1 ; MEF3-like protein 1 ; Paternally expressed gene 10 protein ; Retrotransposon gag domain-containing protein 3 ; Retrotransposon-derived gag-like polyprotein ; Ty3/Gypsy-like protein ; EDR ; KIAA1051 ; MAR2 ; MART2 ; MEF3L1 ; RGAG3
Categories
Elisa
Function
Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter.
Specificity
Natural and recombinant Human Retrotransposon-derived protein PEG10
Subcellular Location
Nucleus Cytoplasm Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the HepG2 cell line. Colocalized with ALK1.