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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Retinoblastoma-like protein 2

SKU : BHE13809553

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12098h
Alternative Names	130 kDa retinoblastoma-associated protein ; p130 ; Retinoblastoma-related protein 2 ; RBR-2 ; pRb2 ; RB2
Categories	Elisa
Function	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Specificity	Natural and recombinant Human Retinoblastoma-like protein 2
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	RBL2_HUMAN
Method Type	Sandwich
Platform	PF11934
Protein Name	Retinoblastoma-like protein 2
Sensitivity	0.156ng/mL
Sequence	50: MPSGGDQSPP ; PPPPPPAAAA ; SDEEEEDDGE ; AEDAAPPAES ; PTPQIQQRFD ; 100: ELCSRLNMDE ; AARAEAWDSY ; RSMSESYTLE ; GNDLHWLACA ; LYVACRKSVP ; 150: TVSKGTVEGN ; YVSLTRILKC ; SEQSLIEFFN ; KMKKWEDMAN ; LPPHFRERTE ; 200: RLERNFTVSA ; VIFKKYEPIF ; QDIFKYPQEE ; QPRQQRGRKQ ; RRQPCTVSEI ; 250: FHFCWVLFIY ; AKGNFPMISD ; DLVNSYHLLL ; CALDLVYGNA ; LQCSNRKELV ; 300: NPNFKGLSED ; FHAKDSKPSS ; DPPCIIEKLC ; SLHDGLVLEA ; KGIKEHFWKP ; 350: YIRKLYEKKL ; LKGKEENLTG ; FLEPGNFGES ; FKAINKAYEE ; YVLSVGNLDE ; 400: RIFLGEDAEE ; EIGTLSRCLN ; AGSGTETAER ; VQMKNILQQH ; FDKSKALRIS ; 450: TPLTGVRYIK ; ENSPCVTPVS ; TATHSLSRLH ; TMLTGLRNAP ; SEKLEQILRT ; 500: CSRDPTQAIA ; NRLKEMFEIY ; SQHFQPDEDF ; SNCAKEIASK ; HFRFAEMLYY ; 550: KVLESVIEQE ; QKRLGDMDLS ; GILEQDAFHR ; SLLACCLEVV ; TFSYKPPGNF ; 600: PFITEIFDVP ; LYHFYKVIEV ; FIRAEDGLCR ; EVVKHLNQIE ; EQILDHLAWK ; 650: PESPLWEKIR ; DNENRVPTCE ; EVMPPQNLER ; ADEICIAGSP ; LTPRRVTEVR ; 700: ADTGGLGRSI ; TSPTTLYDRY ; SSPPASTTRR ; RLFVENDSPS ; DGGTPGRMPP ; 750: QPLVNAVPVQ ; NVSGETVSVT ; PVPGQTLVTM ; ATATVTANNG ; QTVTIPVQGI ; 800: ANENGGITFF ; PVQVNVGGQA ; QAVTGSIQPL ; SAQALAGSLS ; SQQVTGTTLQ ; 850: VPGQVAIQQI ; SPGGQQQKQG ; QSVTSSSNRP ; RKTSSLSLFF ; RKVYHLAAVR ; 900: LRDLCAKLDI ; SDELRKKIWT ; CFEFSIIQCP ; ELMMDRHLDQ ; LLMCAIYVMA ; 950: KVTKEDKSFQ ; NIMRCYRTQP ; QARSQVYRSV ; LIKGKRKRRN ; SGSSDSRSHQ ; 1000: NSPTELNKDR ; TSRDSSPVMR ; SSSTLPVPQP ; SSAPPTPTRL ; TGANSDMEEE ; 1050: ERGDLIQFYN ; NIYIKQIKTF ; AMKYSQANMD ; APPLSPYPFV ; RTGSPRRIQL ; 1100: SQNHPVYISP ; HKNETMLSPR ; EKIFYYFSNS ; PSKRLREINS ; MIRTGETPTK ; 1139: KRGILLEDGS ; ESPAKRICPE ; NHSALLRRLQ ; DVANDRGSH
Sequence Length	1139
String	Q08999
Sub Unit	Interacts with AATF. Interacts with SUV420H1, SUV420H2 and USP4 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.

Uniprot	Q08999
Gene Name	RBL2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5934
Unigene	Hs.513609

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809553	E12098h	96T	$736		Add to Cart

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