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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Reticulon-4

SKU : BHE13810291

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E12266h
Alternative Names	Foocen ; Neurite outgrowth inhibitor ; Nogo protein ; Neuroendocrine-specific protein ; NSP ; Neuroendocrine-specific protein C homolog ; RTN-x ; Reticulon-5 ; KIAA0886 ; NOGO ; My043 ; SP1507
Categories	Elisa
Function	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Specificity	Natural and recombinant Human Reticulon-4
Subcellular Location	Endoplasmic reticulum membrane Multi-pass membrane protein Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
Entryname	RTN4_HUMAN
Platform	PF02453
Protein Name	Reticulon-4
Sequence	50: MEDLDQSPLV ; SSSDSPPRPQ ; PAFKYQFVRE ; PEDEEEEEEE ; EEEDEDEDLE ; 100: ELEVLERKPA ; AGLSAAPVPT ; APAAGAPLMD ; FGNDFVPPAP ; RGPLPAAPPV ; 150: APERQPSWDP ; SPVSSTVPAP ; SPLSAAAVSP ; SKLPEDDEPP ; ARPPPPPPAS ; 200: VSPQAEPVWT ; PPAPAPAAPP ; STPAAPKRRG ; SSGSVDETLF ; ALPAASEPVI ; 250: RSSAENMDLK ; EQPGNTISAG ; QEDFPSVLLE ; TAASLPSLSP ; LSAASFKEHE ; 300: YLGNLSTVLP ; TEGTLQENVS ; EASKEVSEKA ; KTLLIDRDLT ; EFSELEYSEM ; 350: GSSFSVSPKA ; ESAVIVANPR ; EEIIVKNKDE ; EEKLVSNNIL ; HNQQELPTAL ; 400: TKLVKEDEVV ; SSEKAKDSFN ; EKRVAVEAPM ; REEYADFKPF ; ERVWEVKDSK ; 450: EDSDMLAAGG ; KIESNLESKV ; DKKCFADSLE ; QTNHEKDSES ; SNDDTSFPST ; 500: PEGIKDRSGA ; YITCAPFNPA ; ATESIATNIF ; PLLGDPTSEN ; KTDEKKIEEK ; 550: KAQIVTEKNT ; STKTSNPFLV ; AAQDSETDYV ; TTDNLTKVTE ; EVVANMPEGL ; 600: TPDLVQEACE ; SELNEVTGTK ; IAYETKMDLV ; QTSEVMQESL ; YPAAQLCPSF ; 650: EESEATPSPV ; LPDIVMEAPL ; NSAVPSAGAS ; VIQPSSSPLE ; ASSVNYESIK ; 700: HEPENPPPYE ; EAMSVSLKKV ; SGIKEEIKEP ; ENINAALQET ; EAPYISIACD ; 750: LIKETKLSAE ; PAPDFSDYSE ; MAKVEQPVPD ; HSELVEDSSP ; DSEPVDLFSD ; 800: DSIPDVPQKQ ; DETVMLVKES ; LTETSFESMI ; EYENKEKLSA ; LPPEGGKPYL ; 850: ESFKLSLDNT ; KDTLLPDEVS ; TLSKKEKIPL ; QMEELSTAVY ; SNDDLFISKE ; 900: AQIRETETFS ; DSSPIEIIDE ; FPTLISSKTD ; SFSKLAREYT ; DLEVSHKSEI ; 950: ANAPDGAGSL ; PCTELPHDLS ; LKNIQPKVEE ; KISFSDDFSK ; NGSATSKVLL ; 1000: LPPDVSALAT ; QAEIESIVKP ; KVLVKEAEKK ; LPSDTEKEDR ; SPSAIFSAEL ; 1050: SKTSVVDLLY ; WRDIKKTGVV ; FGASLFLLLS ; LTVFSIVSVT ; AYIALALLSV ; 1100: TISFRIYKGV ; IQAIQKSDEG ; HPFRAYLESE ; VAISEELVQK ; YSNSALGHVN ; 1150: CTIKELRRLF ; LVDDLVDSLK ; FAVLMWVFTY ; VGALFNGLTL ; LILALISLFS ; 1192: VPVIYERHQA ; QIDHYLGLAN ; KNVKDAMAKI ; QAKIPGLKRK ; AE
Sequence Length	1192
String	Q9NQC3
Sub Unit	Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact with BACE1 and BACE2. Interacts with RTN4IP1. Interacts with ATL1.

Uniprot	Q9NQC3
Gene Name	RTN4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:57142
Unigene	Hs.637850

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810291	E12266h	96T	$736		Add to Cart

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