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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Repulsive guidance molecule A

SKU : BHE13808898

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3256h
Alternative Names	RGM domain family member A ; RGM
Categories	Elisa
Function	Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Specificity	Natural and recombinant Human Repulsive guidance molecule A
Subcellular Location	Cell membrane Lipid-anchor GPI-anchor
Detection Range	0.312-20ng/mL
Entryname	RGMA_HUMAN
Method Type	Sandwich
Platform	PF06534
Protein Name	Repulsive guidance molecule A
Sensitivity	0.196ng/mL
Sequence	50: MQPPRERLVV ; TGRAGWMGMG ; RGAGRSALGF ; WPTLAFLLCS ; FPAATSPCKI ; 100: LKCNSEFWSA ; TSGSHAPASD ; DTPEFCAALR ; SYALCTRRTA ; RTCRGDLAYH ; 150: SAVHGIEDLM ; SQHNCSKDGP ; TSQPRLRTLP ; PAGDSQERSD ; SPEICHYEKS ; 200: FHKHSATPNY ; THCGLFGDPH ; LRTFTDRFQT ; CKVQGAWPLI ; DNNYLNVQVT ; 250: NTPVLPGSAA ; TATSKLTIIF ; KNFQECVDQK ; VYQAEMDELP ; AAFVDGSKNG ; 300: GDKHGANSLK ; ITEKVSGQHV ; EIQAKYIGTT ; IVVRQVGRYL ; TFAVRMPEEV ; 350: VNAVEDWDSQ ; GLYLCLRGCP ; LNQQIDFQAF ; HTNAEGTGAR ; RLAAASPAPT ; 400: APETFPYETA ; VAKCKEKLPV ; EDLYYQACVF ; DLLTTGDVNF ; TLAAYYALED ; 450:
Sequence Length	450
String	Q96B86
Sub Unit	Interacts with NEO1, BMP2 and BMP4.

Uniprot	Q96B86
Gene Name	RGMA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:56963
Unigene	Hs.271277

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808898	E3256h	96T	$736		Add to Cart

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