JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Receptor-interacting serine/threonine-protein kinase 2

SKU : BHE13809500

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E1786h
Alternative Names	CARD-containing interleukin-1 beta-converting enzyme-associated kinase ; CARD-containing IL-1 beta ICE-kinase ; RIP-like-interacting CLARP kinase ; Receptor-interacting protein 2 ; RIP-2 ; Tyrosine-protein kinase RIPK2 ; 2.7.10.2 ; CARDIAK ; RICK ; RIP2 ; UNQ277/PRO314/PRO34092
Categories	Elisa
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Specificity	Natural and recombinant Human Receptor-interacting serine/threonine-protein kinase 2
Subcellular Location	Cytoplasm
Detection Range	78-5000pg/mL
Entryname	RIPK2_HUMAN
Method Type	Sandwich
Platform	PF00619
Protein Name	Receptor-interacting serine/threonine-protein kinase 2
Sensitivity	40pg/mL
Sequence	50: MNGEAICSAL ; PTIPYHKLAD ; LRYLSRGASG ; TVSSARHADW ; RVQVAVKHLH ; 100: IHTPLLDSER ; KDVLREAEIL ; HKARFSYILP ; ILGICNEPEF ; LGIVTEYMPN ; 150: GSLNELLHRK ; TEYPDVAWPL ; RFRILHEIAL ; GVNYLHNMTP ; PLLHHDLKTQ ; 200: NILLDNEFHV ; KIADFGLSKW ; RMMSLSQSRS ; SKSAPEGGTI ; IYMPPENYEP ; 250: GQKSRASIKH ; DIYSYAVITW ; EVLSRKQPFE ; DVTNPLQIMY ; SVSQGHRPVI ; 300: NEESLPYDIP ; HRARMISLIE ; SGWAQNPDER ; PSFLKCLIEL ; EPVLRTFEEI ; 350: TFLEAVIQLK ; KTKLQSVSSA ; IHLCDKKKME ; LSLNIPVNHG ; PQEESCGSSQ ; 400: LHENSGSPET ; SRSLPAPQDN ; DFLSRKAQDC ; YFMKLHHCPG ; NHSWDSTISG ; 450: SQRAAFCDHK ; TTPCSSAIIN ; PLSTAGNSER ; LQPGIAQQWI ; QSKREDIVNQ ; 500: MTEACLNQSL ; DALLSRDLIM ; KEDYELVSTK ; PTRTSKVRQL ; LDTTDIQGEE ; 540: FAKVIVQKLK ; DNKQMGLQPY ; PEILVVSRSP ; SLNLLQNKSM ;
Sequence Length	540
String	O43353
Sub Unit	Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with NOD1 and NOD2. Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway. Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1.

Uniprot	O43353
Gene Name	RIPK2
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8767
Unigene	Hs.103755

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13809500	E1786h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.