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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Ras-related protein Rab-11A

SKU : BHE13808587

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1716h
Alternative Names	YL8 ; RAB11
Categories	Elisa
Function	Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
Specificity	Natural and recombinant Human Ras-related protein Rab-11A
Subcellular Location	Cell membrane Peripheral membrane protein Recycling endosome membrane Peripheral membrane protein Cleavage furrow Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
Detection Range	0.78-50ng/mL
Entryname	RB11A_HUMAN
Method Type	Sandwich
Platform	PF00071
Protein Name	Ras-related protein Rab-11A
Sensitivity	0.34ng/mL
Sequence	50: MGTRDDEYDY ; LFKVVLIGDS ; GVGKSNLLSR ; FTRNEFNLES ; KSTIGVEFAT ; 100: RSIQVDGKTI ; KAQIWDTAGQ ; ERYRAITSAY ; YRGAVGALLV ; YDIAKHLTYE ; 150: NVERWLKELR ; DHADSNIVIM ; LVGNKSDLRH ; LRAVPTDEAR ; AFAEKNGLSF ; 200: IETSALDSTN ; VEAAFQTILT ; EIYRIVSQKQ ; MSDRRENDMS ; PSNNVVPIHV ; 216: PPTTENKPKV ; QCCQNI
Sequence Length	216
String	P62491
Sub Unit	Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAR. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27.

Uniprot	P62491
Gene Name	RAB11A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8766
Unigene	Hs.321541

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808587	E1716h	96T	$736		Add to Cart

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