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Home / Assay Kits / ELISA Kits

ELISA Kit for Human RAC-alpha serine/threonine-protein kinase

SKU : BHE13800751

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0382h
Alternative Names	Protein kinase B ; PKB ; Protein kinase B alpha ; PKB alpha ; Proto-oncogene c-Akt ; RAC-PK-alpha ; PKB ; RAC
Categories	Elisa
Function	AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Specificity	Natural and recombinant Human RAC-alpha serine/threonine-protein kinase
Subcellular Location	Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.
Detection Range	0.78-50ng/mL
Entryname	AKT1_HUMAN
Method Type	Sandwich
Platform	PF00169
Protein Name	RAC-alpha serine/threonine-protein kinase
Sensitivity	0.195ng/mL
Sequence	50: MSDVAIVKEG ; WLHKRGEYIK ; TWRPRYFLLK ; NDGTFIGYKE ; RPQDVDQREA ; 100: PLNNFSVAQC ; QLMKTERPRP ; NTFIIRCLQW ; TTVIERTFHV ; ETPEEREEWT ; 150: TAIQTVADGL ; KKQEEEEMDF ; RSGSPSDNSG ; AEEMEVSLAK ; PKHRVTMNEF ; 200: EYLKLLGKGT ; FGKVILVKEK ; ATGRYYAMKI ; LKKEVIVAKD ; EVAHTLTENR ; 250: VLQNSRHPFL ; TALKYSFQTH ; DRLCFVMEYA ; NGGELFFHLS ; RERVFSEDRA ; 300: RFYGAEIVSA ; LDYLHSEKNV ; VYRDLKLENL ; MLDKDGHIKI ; TDFGLCKEGI ; 350: KDGATMKTFC ; GTPEYLAPEV ; LEDNDYGRAV ; DWWGLGVVMY ; EMMCGRLPFY ; 400: NQDHEKLFEL ; ILMEEIRFPR ; TLGPEAKSLL ; SGLLKKDPKQ ; RLGGGSEDAK ; 450: EIMQHRFFAG ; IVWQHVYEKK ; LSPPFKPQVT ; SETDTRYFDE ; EFTAQMITIT ; 480: PPDQDDSMEC ; VDSERRPHFP ; QFSYSASGTA ;
Sequence Length	480
String	P31749
Sub Unit	Interacts with AGAP2 (isoform 2, PIKE-A), the interaction requires guanine nucleotides and stimulates the kinase activity. Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus). Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with MAP3K5 and TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity. Interacts with TNK2. Interacts with CLK2 and PPP2R5B. Interacts with STK3/MST2 and STK4/MST1.

Uniprot	P31749
Gene Name	AKT1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:207
Unigene	Hs.525622

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SKU	Supplier No.	Size	Your price	Quantity
BHE13800751	E0382h	96T	$536		Add to Cart

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