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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Pyruvate kinase PKM

SKU : BHE13806737

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0588h
Alternative Names	Cytosolic thyroid hormone-binding protein ; CTHBP ; Opa-interacting protein 3 ; OIP-3 ; Pyruvate kinase 2/3 ; Pyruvate kinase muscle isozyme ; Thyroid hormone-binding protein 1 ; THBP1 ; Tumor M2-PK ; p58 ; OIP3 ; PK2 ; PK3 ; PKM2
Categories	Elisa
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Specificity	Natural and recombinant Human Pyruvate kinase PKM
Subcellular Location	Cytoplasm Nucleus Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
Detection Range	1.56-100U/mL
Entryname	KPYM_HUMAN
Method Type	Sandwich
Platform	PF00224
Protein Name	Pyruvate kinase PKM
Sensitivity	0.98U/mL
Sequence	50: MSKPHSEAGT ; AFIQTQQLHA ; AMADTFLEHM ; CRLDIDSPPI ; TARNTGIICT ; 100: IGPASRSVET ; LKEMIKSGMN ; VARLNFSHGT ; HEYHAETIKN ; VRTATESFAS ; 150: DPILYRPVAV ; ALDTKGPEIR ; TGLIKGSGTA ; EVELKKGATL ; KITLDNAYME ; 200: KCDENILWLD ; YKNICKVVEV ; GSKIYVDDGL ; ISLQVKQKGA ; DFLVTEVENG ; 250: GSLGSKKGVN ; LPGAAVDLPA ; VSEKDIQDLK ; FGVEQDVDMV ; FASFIRKASD ; 300: VHEVRKVLGE ; KGKNIKIISK ; IENHEGVRRF ; DEILEASDGI ; MVARGDLGIE ; 350: IPAEKVFLAQ ; KMMIGRCNRA ; GKPVICATQM ; LESMIKKPRP ; TRAEGSDVAN ; 400: AVLDGADCIM ; LSGETAKGDY ; PLEAVRMQHL ; IAREAEAAIY ; HLQLFEELRR ; 450: LAPITSDPTE ; ATAVGAVEAS ; FKCCSGAIIV ; LTKSGRSAHQ ; VARYRPRAPI ; 500: IAVTRNPQTA ; RQAHLYRGIF ; PVLCKDPVQE ; AWAEDVDLRV ; NFAMNVGKAR ; 531: GFFKKGDVVI ; VLTGWRPGSG ; FTNTMRVVPV ; P
Sequence Length	531
String	P14618
Sub Unit	Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate. Binding to certain oncoproteins such as HPV-16 E7 oncoprotein can trigger dimerization. FBP stimulates the formation of tetramers from dimers. Interacts with HERC1, POU5F1 and PML.

Uniprot	P14618
Gene Name	PKM
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5315
Unigene	Hs.534770

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806737	E0588h	96T	$736		Add to Cart

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